Version: 3.2
Updated: 01-Nov-2025
EPH receptor A2
Kinase structure
Kinase:EPHA2 (EphA2)
Family:Eph
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1822
PDB:5EK7
sc-PDB:
KIDFamMap:Search
Release date:2015-12-30
Chain:B
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The orthosteric binding pocket


More entries for 5EK7
5EK7Chain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):64.1° (19Å)
G-rich loop rotation:76.1°
Quality Score:8
Resolution:1.9 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I2
I3
I4
I6
I8
I10
Ligand
No
No
No
No
No
No
No
Protein
Yes
Yes
Yes
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFGLS
Sequence structure:KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFGLS