Version: 3.2
Updated: 29-Oct-2025
Glycogen synthase kinase 3 beta
Kinase structure
Kinase:GSK3B
Family:GSK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:2030
PDB:1Q3W
sc-PDB:
KIDFamMap:Search
Release date:2003-10-21
PubMed: 14529625
Chain:B
Orthosteric ligand:ATU
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 1Q3W
1Q3WChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):56.3° (16.7Å)
G-rich loop rotation:55.9°
Quality Score:8
Resolution:2.3 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
PocketsSubpocketsWaters
front
Cluster
I2
I4
I5
I6
Ligand
Yes
No
Yes
No
Protein
Yes
Yes
Yes
No

Pocket alignment
Uniprot sequence:KVIGNGSFGVVYQVAIKKVFKNRELQIMRKLDCNIVRLRYFNLVLDYVP-ETVYRVARHYIHSFGICHRDIKPQNLLLLCDFGSA
Sequence structure:KVIGNGSFGVVYQVAIKKVFKNRELQIMRKLDCNIVRLRYFNLVLDYVP_ETVYRVARHYIHSFGICHRDIKPQNLLLLCDFGSA

Ligand affinity
ChEMBL ID:CHEMBL50894
Bioaffinities: 62 records for 50 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiens3-phosphoinositide dependent protein kinase-16.96.96.9pKi1
Homo sapiensActivin receptor type-17.27.27.2pKi1
Homo sapiensBR serine/threonine-protein kinase 16.86.86.8pKi1
Homo sapiensCaM kinase II delta5.75.75.7pKi1
Homo sapiensCasein kinase I delta5.15.15.1pKi1
Homo sapiensCasein kinase I gamma 15.75.75.7pKi1
Homo sapiensCasein kinase I gamma 25.45.45.4pKi1
Homo sapiensCasein kinase II alpha6.46.46.4pKi1
Homo sapiensCell division cycle 2-like protein kinase 6555pKi1
Homo sapiensCell division cycle 7-related protein kinase6.46.46.4pKi1
Homo sapiensCell division protein kinase 86.16.16.1pKi1
Homo sapiensCyclin-dependent kinase 17.57.57.5pIC502
Homo sapiensCyclin-dependent kinase 17.57.57.5pKi1
Homo sapiensCyclin-dependent kinase 27.87.87.8pIC501
Homo sapiensCyclin-dependent kinase 27.57.57.5pKi1
Homo sapiensCyclin-dependent kinase 57.47.47.4pIC501
Homo sapiensCyclin-dependent kinase 57.97.97.9pKi1
Homo sapiensCyclin-dependent kinase 97.97.97.9pKi1
Homo sapiensFibroblast growth factor receptor 15.45.45.4pKi1
Homo sapiensGlycogen synthase kinase-3 alpha8.48.48.4pIC501
Homo sapiensGlycogen synthase kinase-3 beta8.47.78.4pIC507
Homo sapiensGlycogen synthase kinase-3 beta7.87.87.8pKi1
Homo sapiensInhibitor of nuclear factor kappa B kinase beta subunit5.75.75.7pKi1
Homo sapiensInterleukin-1 receptor-associated kinase 16.16.16.1pKi1
Homo sapiensMacrophage colony stimulating factor receptor666pKi1
Homo sapiensMacrophage-stimulating protein receptor666pKi1
Homo sapiensMAP kinase ERK25.65.65.6pKi1
Homo sapiensMAP/microtubule affinity-regulating kinase 26.46.46.4pKi1
Homo sapiensMisshapen-like kinase 17.17.17.1pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 26.96.96.9pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 47.47.47.4pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 57.17.17.1pKi1
Homo sapiensMixed lineage kinase 75.25.25.2pKi1
Homo sapiensPAS domain-containing serine/threonine-protein kinase6.46.46.4pKi1
Homo sapiensPhosphorylase kinase gamma subunit 25.95.95.9pKi1
Homo sapiensProtein kinase C delta5.55.55.5pKi1
Homo sapiensProtein kinase N26.16.16.1pKi1
Plasmodium falciparumProtein kinase Pfmrk4.34.34.3pIC502
Homo sapiensRho-associated protein kinase 15.85.85.8pKi1
Homo sapiensRho-associated protein kinase 25.75.75.7pKi1
Homo sapiensRibosomal protein S6 kinase 15.45.45.4pKi1
Homo sapiensSerine/threonine-protein kinase Chk27.77.77.7pKi1
Homo sapiensSerine/threonine-protein kinase c-TAK16.26.26.2pKi1
Homo sapiensSerine/threonine-protein kinase MRCK-A6.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase MST26.76.76.7pKi1
Homo sapiensSerine/threonine-protein kinase PAK 46.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase PIM15.65.65.6pKi1
Homo sapiensSerine/threonine-protein kinase PLK46.86.86.8pKi1
Homo sapiensTestis-specific serine/threonine-protein kinase 2666pKi1
Homo sapiensTyrosine-protein kinase ABL5.85.85.8pKi1
Homo sapiensTyrosine-protein kinase BLK5.95.95.9pKi1
Homo sapiensTyrosine-protein kinase Lyn6.36.36.3pKi1
Homo sapiensTyrosine-protein kinase SRC6.46.46.4pKi1
Homo sapiensVascular endothelial growth factor receptor 36.86.86.8pKi1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 K
60		2 V
61		3 I
62		4 G
63		5 N
64		6 G
65		7 S
66		8 F
67		9 G
68		10 V
69		11 V
70		12 Y
71		13 Q
72		14 V
82		15 A
83		16 I
84		17 K
85		18 K
86		19 V
87		20 F
93
••••
αC b.l IV
21 K
94		22 N
95		23 R
96		24 E
97		25 L
98		26 Q
99		27 I
100		28 M
101		29 R
102		30 K
103		31 L
104		32 D
105		33 C
107		34 N
108		35 I
109		36 V
110		37 R
111		38 L
112		39 R
113		40 Y
114
IV V GK hinge linker αD αE
41 F
115		42 N
129		43 L
130		44 V
131		45 L
132		46 D
133		47 Y
134		48 V
135		49 P
136		50 _
_		51 E
137		52 T
138		53 V
139		54 Y
140		55 R
141		56 V
142		57 A
143		58 R
144		59 H
145		60 Y
171
•••••••••
αE VI c.l VII VIII x
61 I
172		62 H
173		63 S
174		64 F
175		65 G
176		66 I
177		67 C
178		68 H
179		69 R
180		70 D
181		71 I
182		72 K
183		73 P
184		74 Q
185		75 N
186		76 L
187		77 L
188		78 L
189		79 L
198		80 C
199
••
DFG a.l
81 D
200		82 F
201		83 G
202		84 S
203		85 A
204
•

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