PDB-code
| Kinase structure | |
| Kinase: | EPHB3 (EphB3) |
| Family: | Eph |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1832 |
| PDB: | 5L6P |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2016-08-10 |
| PubMed: | 27478969 |
| Chain: | A |
| Orthosteric ligand: | 6P8 |
 | |
| Structural information | |
| DFG conformation: | out-like |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 67.6° (20.5Å) |
| G-rich loop rotation: | 76.7° |
| Quality Score: | 8.8 |
| Resolution: | 2.26 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 4 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front gate back | BP-I-B | |||
| Pocket alignment | |
| Uniprot sequence: | EVIGAGEFGEVCRVAIKTLDFLSEASIMGQFDPNIIRLEGVMILTEFMENCALDSFLRLYLSEMNYVHRDLAARNILVVSDFGLS |
| Sequence structure: | EVIGAGEFGEVCRVAIKTLDFLSEASIMGQFDPNIIRLEGVMILTEFMENCALDSFLRLYLSEMNYVHRDLAARNILVVSDFGLS |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 637 | 2 V 638 | 3 I 639 | 4 G 640 | 5 A 641 | 6 G 642 | 7 E 643 | 8 F 644 | 9 G 645 | 10 E 646 | 11 V 647 | 12 C 648 | 13 R 649 | 14 V 662 | 15 A 663 | 16 I 664 | 17 K 665 | 18 T 666 | 19 L 667 | 20 D 678 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 679 | 22 L 680 | 23 S 681 | 24 E 682 | 25 A 683 | 26 S 684 | 27 I 685 | 28 M 686 | 29 G 687 | 30 Q 688 | 31 F 689 | 32 D 690 | 33 P 692 | 34 N 693 | 35 I 694 | 36 I 695 | 37 R 696 | 38 L 697 | 39 E 698 | 40 G 699 |
| • | • | ||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 700 | 42 M 708 | 43 I 709 | 44 L 710 | 45 T 711 | 46 E 712 | 47 F 713 | 48 M 714 | 49 E 715 | 50 N 716 | 51 C 717 | 52 A 718 | 53 L 719 | 54 D 720 | 55 S 721 | 56 F 722 | 57 L 723 | 58 R 724 | 59 L 725 | 60 Y 748 |
| • | • | •• | •• | • | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 749 | 62 S 750 | 63 E 751 | 64 M 752 | 65 N 753 | 66 Y 754 | 67 V 755 | 68 H 756 | 69 R 757 | 70 D 758 | 71 L 759 | 72 A 760 | 73 A 761 | 74 R 762 | 75 N 763 | 76 I 764 | 77 L 765 | 78 V 766 | 79 V 774 | 80 S 775 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 776 | 82 F 777 | 83 G 778 | 84 L 779 | 85 S 780 | |||||||||||||||
| • | • | • | |||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
