Version: 3.2
Updated: 24-Dec-2025
Platelet derived growth factor receptor alpha
Kinase structure
Kinase:PDGFRA (PDGFRa)
Family:PDGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1803
PDB:5K5X
sc-PDB:
KIDFamMap:Search
Release date:2016-08-17
PubMed: 27349873
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):63.4° (19.2Å)
G-rich loop rotation:45.6°
Quality Score:8.6
Resolution:2.17 Å
Missing Residues:0
Missing Atoms:6
Ligand binding mode
Waters
Cluster
I1
I5
I6
Ligand
No
No
No
Protein
Yes
Yes
No

Pocket alignment
Uniprot sequence:RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIITEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA
Sequence structure:RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIITEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGLA