Version: 3.2
Updated: 01-Nov-2025
EPH receptor A2
Kinase structure
Kinase:EPHA2 (EphA2)
Family:Eph
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1822
PDB:5IA0
sc-PDB:
KIDFamMap:Search
Release date:2016-11-09
PubMed: 27768280
Chain:A
(Alternate) Model:B
Orthosteric ligand:A5B
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 5IA0
5IA0Alternative model: AChain: A
5IA0Alternative model: AChain: B
5IA0Alternative model: AChain: C
5IA0Alternative model: BChain: B
5IA0Alternative model: BChain: C


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):66° (19.5Å)
G-rich loop rotation:77.7°
Quality Score:7.2
Resolution:1.95 Å
Missing Residues:2
Missing Atoms:0
Ligand binding mode
PocketsSubpocketsWaters
front
Cluster
I1
I4
I6
I10
Ligand
Yes
No
Yes
No
Protein
Yes
Yes
Yes
No

Pocket alignment
Uniprot sequence:KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFGLS
Sequence structure:KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARNILVVSDFG__

Ligand affinity
ChEMBL ID:CHEMBL483158
Bioaffinities: 59 records for 40 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiens3-phosphoinositide dependent protein kinase-1777pKi1
Homo sapiensBR serine/threonine-protein kinase 15.75.75.7pKi1
Homo sapienscAMP-dependent protein kinase alpha-catalytic subunit6.26.26.2pKi1
Homo sapiensCasein kinase II alpha5.75.75.7pKi1
Homo sapiensCell division protein kinase 85.55.55.5pKi1
Homo sapiensDual specificity protein kinase CLK45.55.55.5pKi1
Homo sapiensEphrin type-A receptor 27.57.57.5pKi1
Homo sapiensEpidermal growth factor receptor erbB16.76.76.7pKi1
Homo sapiensFibroblast growth factor receptor 16.56.56.5pKi1
Homo sapiensFibroblast growth factor receptor 36.76.76.7pKi1
Homo sapiensFocal adhesion kinase 16.96.96.9pKi1
Homo sapiensG protein-coupled receptor kinase 55.45.45.4pKi1
Homo sapiensLeucine-rich repeat serine/threonine-protein kinase 26.16.16.1pKi1
Homo sapiensLeukocyte tyrosine kinase receptor6.46.46.4pKi1
Homo sapiensLIM domain kinase 1666pKi1
Homo sapiensNerve growth factor receptor Trk-A5.85.85.8pKi1
Homo sapiensNeurotrophic tyrosine kinase receptor type 2666pKi1
Homo sapiensNT-3 growth factor receptor6.46.46.4pKi1
Homo sapiensProto-oncogene tyrosine-protein kinase ROS6.86.86.8pKi1
Homo sapiensReceptor protein-tyrosine kinase erbB-25.95.95.9pKi1
Homo sapiensReceptor protein-tyrosine kinase erbB-45.65.65.6pKi1
Homo sapiensRibosomal protein S6 kinase alpha 36.16.16.1pKi2
Homo sapiensSerine/threonine-protein kinase 25.85.85.8pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-A8.9710.4pIC5010
Homo sapiensSerine/threonine-protein kinase Aurora-A9.39.39.3pKi1
Mus musculusSerine/threonine-protein kinase Aurora-A999pIC501
Mus musculusSerine/threonine-protein kinase Aurora-A9.59.59.5pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-B6.45.88.8pIC506
Homo sapiensSerine/threonine-protein kinase Aurora-B8.58.58.5pKi1
Homo sapiensSerine/threonine-protein kinase PIM35.15.15.1pKi1
Homo sapiensSerine/threonine-protein kinase PLK47.47.47.4pKi1
Homo sapiensSerine/threonine-protein kinase SRPK15.65.65.6pKi1
Homo sapiensTyrosine kinase non-receptor protein 26.16.16.1pKi1
Homo sapiensTyrosine-protein kinase ABL6.36.36.3pKi1
Homo sapiensTyrosine-protein kinase BLK7.47.47.4pKi1
Homo sapiensTyrosine-protein kinase BTK6.26.26.2pKi1
Homo sapiensTyrosine-protein kinase FER777pKi1
Homo sapiensTyrosine-protein kinase FRK777pKi1
Homo sapiensTyrosine-protein kinase LCK6.56.56.5pIC501
Homo sapiensTyrosine-protein kinase LCK6.56.56.5pKi1
Homo sapiensTyrosine-protein kinase receptor RET6.46.46.4pKi1
Homo sapiensTyrosine-protein kinase SRC6.56.56.5pKi1
Homo sapiensVascular endothelial growth factor receptor 16.16.16.1pKi1
Homo sapiensVascular endothelial growth factor receptor 26.56.56.5pKi1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 K
617		2 V
618		3 I
619		4 G
620		5 A
621		6 G
622		7 E
623		8 F
624		9 G
625		10 E
626		11 V
627		12 Y
628		13 K
629		14 V
643		15 A
644		16 I
645		17 K
646		18 T
647		19 L
648		20 D
659
••••••••
αC b.l IV
21 F
660		22 L
661		23 G
662		24 E
663		25 A
664		26 G
665		27 I
666		28 M
667		29 G
668		30 Q
669		31 F
670		32 S
671		33 H
673		34 N
674		35 I
675		36 I
676		37 R
677		38 L
678		39 E
679		40 G
680
•
IV V GK hinge linker αD αE
41 V
681		42 M
689		43 I
690		44 I
691		45 T
692		46 E
693		47 Y
694		48 M
695		49 E
696		50 N
697		51 G
698		52 A
699		53 L
700		54 D
701		55 K
702		56 F
703		57 L
704		58 R
705		59 E
706		60 Y
729
••••••••••
αE VI c.l VII VIII x
61 L
730		62 A
731		63 N
732		64 M
733		65 N
734		66 Y
735		67 V
736		68 H
737		69 R
738		70 D
739		71 L
740		72 A
741		73 A
742		74 R
743		75 N
744		76 I
745		77 L
746		78 V
747		79 V
755		80 S
756
•••
DFG a.l
81 D
757		82 F
758		83 G
759		84 _
_		85 _
_
•

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