Epidermal growth factor receptor
Kinase structure
Kinase:EGFR
Family:EGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1797
PDB:2J5E
sc-PDB:
KIDFamMap:Search
Release date:2007-02-27
PubMed: 17334377
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58.9° (18.2Å)
G-rich loop rotation:24.1°
Quality Score:8
Resolution:3.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I6
I10
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Sequence structure:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGXLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA