PDB-code
| Kinase structure | |
| Kinase: | SRPK2 |
| Family: | SRPK |
| Group: | CMGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2209 |
| PDB: | 5MYV |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2017-05-10 |
| PubMed: | 28135068 |
| Chain: | B |
| (Alternate) Model: | A |
| Orthosteric ligand: | W4A |
 | |
| More entries for 5MYV | |||||
| 5MYV | Alternative model: | A | Chain: | A | |
| 5MYV | Alternative model: | A | Chain: | C | |
| 5MYV | Alternative model: | A | Chain: | D | |
| 5MYV | Alternative model: | B | Chain: | A | |
| 5MYV | Alternative model: | B | Chain: | B | |
| 5MYV | Alternative model: | B | Chain: | C | |
| 5MYV | Alternative model: | B | Chain: | D | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 53.8° (17Å) |
| G-rich loop rotation: | 59.1° |
| Quality Score: | 8 |
| Resolution: | 2.9 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I5 | Ligand No | Protein Yes | |
| Pocket alignment | |
| Uniprot sequence: | RKLGWGHFSTVWLVAMKVVTALDEIKLLKCVRDMVVQLIDDCMVFEVLG-HHLLKWIIKLHSKCKIIHTDIKPENILMIADLGNA |
| Sequence structure: | RKLGWGHFSTVWLVAMKVVTALDEIKLLKCVRDMVVQLIDDCMVFEVLG_HHLLKWIIKLHSKCKIIHTDIKPENILMIADLGNA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 96 | 2 K 97 | 3 L 98 | 4 G 99 | 5 W 100 | 6 G 101 | 7 H 102 | 8 F 103 | 9 S 104 | 10 T 105 | 11 V 106 | 12 W 107 | 13 L 108 | 14 V 118 | 15 A 119 | 16 M 120 | 17 K 121 | 18 V 122 | 19 V 123 | 20 T 132 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 A 133 | 22 L 134 | 23 D 135 | 24 E 136 | 25 I 137 | 26 K 138 | 27 L 139 | 28 L 140 | 29 K 141 | 30 C 142 | 31 V 143 | 32 R 144 | 33 D 154 | 34 M 155 | 35 V 156 | 36 V 157 | 37 Q 158 | 38 L 159 | 39 I 160 | 40 D 161 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 D 162 | 42 C 174 | 43 M 175 | 44 V 176 | 45 F 177 | 46 E 178 | 47 V 179 | 48 L 180 | 49 G 181 | 50 _ _ | 51 H 182 | 52 H 183 | 53 L 184 | 54 L 185 | 55 K 186 | 56 W 187 | 57 I 188 | 58 I 189 | 59 K 190 | 60 L 215 |
| •• | • | •• | • | •• | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 H 216 | 62 S 217 | 63 K 218 | 64 C 219 | 65 K 220 | 66 I 221 | 67 I 222 | 68 H 223 | 69 T 224 | 70 D 225 | 71 I 226 | 72 K 227 | 73 P 228 | 74 E 229 | 75 N 230 | 76 I 231 | 77 L 232 | 78 M 233 | 79 I 539 | 80 A 540 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 541 | 82 L 542 | 83 G 543 | 84 N 544 | 85 A 545 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
