MAP kinase interacting serine/threonine kinase 2
Kinase structure
Kinase:MKNK2 (MNK2)
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2105
PDB:2AC3
sc-PDB:
KIDFamMap:Search
Release date:2005-10-04
PubMed: 16216586
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:out
G-rich loop angle (distance):54.3° (16.6Å)
G-rich loop rotation:59.3°
Quality Score:8
Resolution:2.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I3
I7
I8
Ligand
No
No
No
No
Protein
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:DVLGEGAHARVQTYAVKIIRVFREVEMLYQCQRNVLELIEFYLVFEKMRGGSILSHIHKFLHNKGIAHRDLKPENILCICDFDLG
Sequence structure:DVLGEGAHARVQTYAVKIIRVFREVEMLYQCQRNVLELIEFYLVFEKMRGGSILSHIHKFLHNKGIAHRDLKPENILCICDFDLG