Version: 3.2
Updated: 29-Oct-2025
WNK lysine deficient protein kinase 3
Kinase structure
Kinase:WNK3 (Wnk3)
Family:WNK
Group:Other
Species:HUMAN
IUPHAR/BPS ID:2282
PDB:5O2B
sc-PDB:
KIDFamMap:Search
Release date:2017-06-28
Chain:B
(Alternate) Model:B
Orthosteric ligand:KS1
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 5O2B
5O2BAlternative model: AChain: A
5O2BAlternative model: AChain: B
5O2BAlternative model: BChain: A


Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):55.6° (15.8Å)
G-rich loop rotation:35.8°
Quality Score:8
Resolution:2.04 Å
Missing Residues:0
Missing Atoms:20
Ligand binding mode
PocketsSubpocketsWaters
front
gate
Cluster
I1
I7
Ligand
No
Yes
Protein
Yes
No

Pocket alignment
Uniprot sequence:IELGRGAFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA
Sequence structure:IELGRGAFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA

Ligand affinity
ChEMBL ID:CHEMBL1081312
Bioaffinities: 66 records for 54 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensActivin receptor type-17.27.27.2pKi1
Homo sapiensALK tyrosine kinase receptor6.26.26.2pKi1
Homo sapiensAMP-activated protein kinase, alpha-1 subunit5.65.65.6pKi1
Homo sapienscAMP-dependent protein kinase alpha-catalytic subunit6.16.16.1pKi1
Homo sapiensCasein kinase I alpha7.47.47.4pKi1
Homo sapiensCell division protein kinase 85.95.95.9pKi1
Homo sapiensc-Jun N-terminal kinase 15.65.65.6pKi1
Homo sapiensc-Jun N-terminal kinase 25.95.95.9pKi1
Homo sapiensCyclin-dependent kinase 55.95.95.9pKi1
Homo sapiensDeath-associated protein kinase 35.35.35.3pKi1
Homo sapiensDNA-dependent protein kinase7.27.27.2pIC501
Homo sapiensDual specificity mitogen-activated protein kinase kinase 16.46.46.4pKi1
Homo sapiensDual specificity mitogen-activated protein kinase kinase 2666pKi1
Homo sapiensDual specificity protein kinase CLK2666pKi1
Homo sapiensDual specificity protein kinase CLK46.16.16.1pKi1
Homo sapiensEphrin type-B receptor 46.76.76.7pIC501
Homo sapiensEpidermal growth factor receptor erbB16.66.66.6pIC502
Homo sapiensFibroblast growth factor receptor 1777pKi1
Homo sapiensFocal adhesion kinase 15.95.95.9pKi1
Homo sapiensGlycogen synthase kinase-3 alpha5.75.75.7pKi1
Homo sapiensInhibitor of nuclear factor kappa B kinase epsilon subunit5.85.85.8pKi1
Homo sapiensInsulin-like growth factor I receptor6.46.46.4pKi1
Homo sapiensLeucine-rich repeat serine/threonine-protein kinase 27.27.27.2pKi1
Homo sapiensLeukocyte tyrosine kinase receptor6.86.86.8pKi1
Homo sapiensLIM domain kinase 16.86.86.8pKi1
Homo sapiensMacrophage colony stimulating factor receptor6.46.46.4pKi1
Homo sapiensMacrophage-stimulating protein receptor6.96.96.9pKi1
Homo sapiensMAP kinase p38 alpha5.65.65.6pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 26.56.56.5pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 46.26.26.2pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 55.95.95.9pKi1
Homo sapiensPlatelet-derived growth factor receptor alpha6.56.56.5pKi1
Homo sapiensPlatelet-derived growth factor receptor beta6.46.46.4pKi1
Homo sapiensProtein kinase C nu6.66.66.6pKi1
Homo sapiensProtein kinase C theta6.36.36.3pKi1
Homo sapiensRho-associated protein kinase 16.76.76.7pKi1
Homo sapiensRho-associated protein kinase 27.47.47.4pKi1
Homo sapiensSerine-protein kinase ATR5.95.95.9pIC501
Homo sapiensSerine/threonine-protein kinase c-TAK16.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase mTOR888pIC502
Homo sapiensSerine/threonine-protein kinase PAK 46.26.26.2pKi1
Homo sapiensSerine/threonine-protein kinase TAO15.65.65.6pKi1
Homo sapiensTyrosine kinase non-receptor protein 26.46.46.4pKi1
Homo sapiensTyrosine-protein kinase ABL7.87.88.7pIC503
Homo sapiensTyrosine-protein kinase ABL7.87.87.8pKi1
Homo sapiensTyrosine-protein kinase BTK5.85.85.8pKi1
Homo sapiensTyrosine-protein kinase FYN7.17.17.1pKi1
Homo sapiensTyrosine-protein kinase HCK8.18.18.1pIC502
Homo sapiensTyrosine-protein kinase JAK2666pKi2
Homo sapiensTyrosine-protein kinase LCK6.86.86.8pKi1
Homo sapiensTyrosine-protein kinase receptor RET8.98.98.9pKi1
Homo sapiensTyrosine-protein kinase receptor TYRO36.16.16.1pKi1
Homo sapiensTyrosine-protein kinase SRC7.97.97.9pIC503
Homo sapiensVascular endothelial growth factor receptor 17.27.27.2pKi1
Homo sapiensVascular endothelial growth factor receptor 27.97.47.9pIC503
Homo sapiensVascular endothelial growth factor receptor 28.38.38.3pKi1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 I
151		2 E
152		3 L
153		4 G
154		5 R
155		6 G
156		7 A
157		8 F
158		9 K
159		10 T
160		11 V
161		12 Y
162		13 K
163		14 V
173		15 A
174		16 W
175		17 C
176		18 E
177		19 L
178		20 R
190
••••••••
αC b.l IV
21 F
191		22 K
192		23 E
193		24 E
194		25 A
195		26 E
196		27 M
197		28 L
198		29 K
199		30 G
200		31 L
201		32 Q
202		33 P
204		34 N
205		35 I
206		36 V
207		37 R
208		38 F
209		39 Y
210		40 D
211
IV V GK hinge linker αD αE
41 S
212		42 V
224		43 L
225		44 V
226		45 T
227		46 E
228		47 L
229		48 M
230		49 T
231		50 S
232		51 G
233		52 T
234		53 L
235		54 K
236		55 T
237		56 Y
238		57 L
239		58 K
240		59 R
241		60 H
265
•••••••
αE VI c.l VII VIII x
61 T
266		62 R
267		63 T
268		64 P
269		65 P
270		66 I
271		67 I
272		68 H
273		69 R
274		70 D
275		71 L
276		72 K
277		73 C
278		74 D
279		75 N
280		76 I
281		77 F
282		78 I
283		79 I
292		80 G
293
••
DFG a.l
81 D
294		82 L
295		83 G
296		84 L
297		85 A
298
•••

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