PDB-code
| Kinase structure | |
| Kinase: | AXL |
| Family: | Axl |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1835 |
| PDB: | 5U6B |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2017-07-26 |
| PubMed: | 28724631 |
| Chain: | D |
| Orthosteric ligand: | 7YS |
 | |
| More entries for 5U6B | |||
| 5U6B | Chain: | A | |
| 5U6B | Chain: | B | |
| 5U6B | Chain: | C | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 58.3° (17.8Å) |
| G-rich loop rotation: | 77.6° |
| Quality Score: | 8 |
| Resolution: | 2.84 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front | FP-I | |||
| Pocket alignment | |
| Uniprot sequence: | KTLGEGEFGAVMEVAVKTMDFLSEAVCMKEFDPNVMRLIGVVVILPFMKHGDLHSFLLYYLSTKRFIHRDLAARNCMLVADFGLS |
| Sequence structure: | KTLGEGEFGAVMEVAVKTMDFLSEAVCMKEFDPNVMRLIGVVVILPFMKHGDLHSFLLYYLSTKRFIHRDLAARNCMLVADFGLS |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 540 | 2 T 541 | 3 L 542 | 4 G 543 | 5 E 544 | 6 G 545 | 7 E 546 | 8 F 547 | 9 G 548 | 10 A 549 | 11 V 550 | 12 M 551 | 13 E 552 | 14 V 564 | 15 A 565 | 16 V 566 | 17 K 567 | 18 T 568 | 19 M 569 | 20 D 581 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 582 | 22 L 583 | 23 S 584 | 24 E 585 | 25 A 586 | 26 V 587 | 27 C 588 | 28 M 589 | 29 K 590 | 30 E 591 | 31 F 592 | 32 D 593 | 33 P 595 | 34 N 596 | 35 V 597 | 36 M 598 | 37 R 599 | 38 L 600 | 39 I 601 | 40 G 602 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 603 | 42 V 617 | 43 V 618 | 44 I 619 | 45 L 620 | 46 P 621 | 47 F 622 | 48 M 623 | 49 K 624 | 50 H 625 | 51 G 626 | 52 D 627 | 53 L 628 | 54 H 629 | 55 S 630 | 56 F 631 | 57 L 632 | 58 L 633 | 59 Y 634 | 60 Y 662 |
| • | • | • | •• | • | • | ••• | • | ||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 663 | 62 S 664 | 63 T 665 | 64 K 666 | 65 R 667 | 66 F 668 | 67 I 669 | 68 H 670 | 69 R 671 | 70 D 672 | 71 L 673 | 72 A 674 | 73 A 675 | 74 R 676 | 75 N 677 | 76 C 678 | 77 M 679 | 78 L 680 | 79 V 688 | 80 A 689 |
| • | • | • | • | ||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 690 | 82 F 691 | 83 G 692 | 84 L 693 | 85 S 694 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
