Version: 3.2
Updated: 01-Nov-2025
Protein kinase, membrane associated tyrosine/threonine 1
Kinase structure
Kinase:PKMYT1 (MYT1)
Family:WEE
Group:Other
Species:HUMAN
IUPHAR/BPS ID:2167
PDB:5VCW
sc-PDB:
KIDFamMap:Search
Release date:2017-08-23
PubMed: 28792760
Chain:A
Orthosteric ligand:93J
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 5VCW
5VCWChain: B


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):59.8° (18.5Å)
G-rich loop rotation:51°
Quality Score:8
Resolution:2.25 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
PocketsSubpocketsWaters
front
gate
BP-I-A
BP-I-B
Cluster
I4
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTELC-GPSLQQHCEAHLHSQGLVHLDVKPANIFLLGDFGLL
Sequence structure:SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTELC_GPSLQQHCEAHLHSQGLVHLDVKPANIFLLGDFGLL

Ligand affinity
ChEMBL ID:CHEMBL607707
Bioaffinities: 197 records for 103 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensAdaptor-associated kinase5.55.55.6pKd2
Homo sapiensALK tyrosine kinase receptor5.25.25.2pKd1
Homo sapiensBMP-2-inducible protein kinase5.75.76.3pKd2
Homo sapiensCaM kinase I delta5.25.25.4pKd2
Homo sapiensCaM-kinase kinase alpha5.35.35.3pKd1
Homo sapiensCaM-kinase kinase beta5.65.65.7pKd2
Homo sapiensCasein kinase I delta666pKd1
Homo sapiensCasein kinase I epsilon777pKd2
Homo sapiensCasein kinase I isoform alpha-like666pKd1
Homo sapiensCitron Rho-interacting kinase6.56.56.5pKd1
Homo sapiensDeath-associated protein kinase 35.45.45.6pKd2
Homo sapiensDual specificity mitogen-activated protein kinase kinase 16.46.46.4pKd1
Homo sapiensDual specificity mitogen-activated protein kinase kinase 26.16.16.1pKd1
Homo sapiensDual specificity protein kinase CLK25.85.86.2pKd2
Homo sapiensDual specificity protein kinase CLK35.35.35.7pKd2
Homo sapiensDual specificity protein kinase CLK45.45.45.5pKd2
Homo sapiensDual specificity tyrosine-phosphorylation-regulated kinase 1B5.45.45.4pKd1
Homo sapiensDual specificty protein kinase CLK15.55.56pKd2
Homo sapiensEphrin type-A receptor 35.45.45.4pKd2
Homo sapiensEphrin type-A receptor 56.26.26.2pKd1
Homo sapiensEphrin type-A receptor 65.45.45.4pKd1
Homo sapiensEphrin type-A receptor 85.55.56.4pKd2
Homo sapiensEphrin type-B receptor 15.45.45.4pKd1
Homo sapiensEphrin type-B receptor 45.65.65.9pKd2
Homo sapiensEpidermal growth factor receptor erbB17.44.19.6pIC5015
Homo sapiensEpidermal growth factor receptor erbB19.499.6pKd11
Homo sapiensEukaryotic translation initiation factor 2-alpha kinase 46.56.56.5pKd1
Homo sapiensFocal adhesion kinase 15.45.45.4pKd1
Homo sapiensHepatocyte growth factor receptor5.25.25.2pKd1
Homo sapiensInterferon-induced, double-stranded RNA-activated protein kinase5.75.75.7pKd1
Homo sapiensMacrophage colony stimulating factor receptor5.45.45.4pKd1
Homo sapiensMitogen-activated protein kinase kinase kinase 46.66.66.9pKd2
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 16.66.66.6pKd1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 36.86.86.8pKd1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 46.56.56.5pKd1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 5888.4pKd2
Homo sapiensMixed lineage kinase 75.95.95.9pKd1
Homo sapiensmyosin light chain kinase 25.45.45.8pKd2
Homo sapiensMyotonin-protein kinase7.27.27.2pKd1
Homo sapiensNUAK family SNF1-like kinase 25.65.65.6pKd1
Homo sapiensPhosphatidylinositol-5-phosphate 4-kinase type-2 beta5.65.65.6pKd1
Homo sapiensPhosphorylase kinase gamma subunit 15.55.55.8pKd2
Homo sapiensPhosphorylase kinase gamma subunit 25.65.65.6pKd1
Homo sapiensProtein kinase C delta5.35.35.3pKd1
Homo sapiensProto-oncogene tyrosine-protein kinase MER5.95.95.9pKd1
Homo sapiensReceptor protein-tyrosine kinase erbB-25.95.95.9pIC503
Homo sapiensReceptor protein-tyrosine kinase erbB-26.36.37.1pKd2
Homo sapiensRibosomal protein S6 kinase alpha 25.15.15.1pKd4
Homo sapiensSerine/threonine-protein kinase 106.56.57pKd2
Homo sapiensSerine/threonine-protein kinase 17A6.76.77.2pKd2
Homo sapiensSerine/threonine-protein kinase 17B5.45.45.9pKd2
Homo sapiensSerine/threonine-protein kinase 26.46.46.6pKd2
Homo sapiensSerine/threonine-protein kinase 245.75.75.7pKd1
Homo sapiensSerine/threonine-protein kinase 255.55.55.5pKd1
Homo sapiensSerine/threonine-protein kinase 32B5.25.25.2pKd1
Homo sapiensSerine/threonine-protein kinase 335.45.45.4pKd1
Homo sapiensSerine/threonine-protein kinase 365.45.45.9pKd2
Homo sapiensSerine/threonine-protein kinase 38-like5.55.55.5pKd1
Homo sapiensSerine/threonine-protein kinase Chk15.75.75.7pKd1
Homo sapiensSerine/threonine-protein kinase DCLK35.35.35.3pKd1
Homo sapiensSerine/threonine-protein kinase GAK8.28.28.8pKd3
Homo sapiensSerine/threonine-protein kinase MARK15.45.45.4pKd1
Homo sapiensSerine/threonine-protein kinase MST15.45.45.4pKd2
Homo sapiensSerine/threonine-protein kinase MST25.65.65.6pKd1
Mus musculusSerine/threonine-protein kinase MST2666pKd1
Homo sapiensSerine/threonine-protein kinase Nek15.45.45.4pKd1
Homo sapiensSerine/threonine-protein kinase NEK26.26.26.2pIC501
Homo sapiensSerine/threonine-protein kinase NEK26.26.26.9pKd2
Homo sapiensSerine/threonine-protein kinase PAK 15.55.55.7pKd2
Homo sapiensSerine/threonine-protein kinase PCTAIRE-1555pKd1
Homo sapiensSerine/threonine-protein kinase SIK25.45.45.4pKd1
Homo sapiensSerine/threonine-protein kinase TNNI3K5.15.15.1pKd1
Homo sapiensSerine/threonine-protein kinase WEE16.16.16.8pKd2
Homo sapiensTRAF2- and NCK-interacting kinase6.86.87.4pKd2
Homo sapiensTyrosine- and threonine-specific cdc2-inhibitory kinase65.56pKd3
Homo sapiensTyrosine kinase non-receptor protein 25.35.36.1pKd2
Homo sapiensTyrosine-protein kinase ABL6.65.87pKd14
Homo sapiensTyrosine-protein kinase ABL26.46.46.8pKd2
Homo sapiensTyrosine-protein kinase BLK7.17.17.1pKd1
Homo sapiensTyrosine-protein kinase BMX5.15.15.1pKd1
Homo sapiensTyrosine-protein kinase BTK5.35.35.8pKd2
Homo sapiensTyrosine-protein kinase CSK5.55.55.6pKd2
Homo sapiensTyrosine-protein kinase FER5.15.16.6pKd2
Homo sapiensTyrosine-protein kinase FES5.25.25.2pKd1
Homo sapiensTyrosine-protein kinase FGR666pKd1
Homo sapiensTyrosine-protein kinase FRK6.26.26.7pKd2
Homo sapiensTyrosine-protein kinase FYN5.65.65.8pKd2
Homo sapiensTyrosine-protein kinase HCK5.65.65.6pKd2
Homo sapiensTyrosine-protein kinase ITK/TSK5.65.65.6pKd1
Homo sapiensTyrosine-protein kinase JAK25.75.75.7pKd2
Homo sapiensTyrosine-protein kinase JAK37.67.67.6pKd2
Homo sapiensTyrosine-protein kinase LCK777.4pKd2
Homo sapiensTyrosine-protein kinase Lyn666.1pKd2
Homo sapiensTyrosine-protein kinase receptor FLT35.65.55.7pKd3
Homo sapiensTyrosine-protein kinase receptor Tie-1666pKd1
Homo sapiensTyrosine-protein kinase receptor TYRO35.45.45.4pKd1
Homo sapiensTyrosine-protein kinase receptor UFO666pKd1
Homo sapiensTyrosine-protein kinase SRC6.66.66.9pKd2
Homo sapiensTyrosine-protein kinase SYK5.15.15.9pKd2
Homo sapiensTyrosine-protein kinase TIE-25.55.55.5pKd1
Homo sapiensTyrosine-protein kinase TXK5.35.35.3pKd1
Homo sapiensTyrosine-protein kinase YES666.1pKd2
Mus musculusULK3 kinase5.45.45.4pKd1
Homo sapiensUncharacterized aarF domain-containing protein kinase 45.25.25.2pKd1
Homo sapiensVascular endothelial growth factor receptor 25.55.55.5pIC501
Homo sapiensWee1-like protein kinase 26.36.36.3pKd1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 S
114		2 R
115		3 L
116		4 G
117		5 H
118		6 G
119		7 S
120		8 Y
121		9 G
122		10 E
123		11 V
124		12 F
125		13 K
126		14 Y
136		15 A
137		16 V
138		17 K
139		18 R
140		19 S
141		20 R
153
••••••
αC b.l IV
21 K
154		22 L
155		23 A
156		24 E
157		25 V
158		26 G
159		27 S
160		28 H
161		29 E
162		30 K
163		31 V
164		32 G
165		33 P
168		34 C
169		35 C
170		36 V
171		37 R
172		38 L
173		39 E
174		40 Q
175
•
IV V GK hinge linker αD αE
41 A
176		42 Y
184		43 L
185		44 Q
186		45 T
187		46 E
188		47 L
189		48 C
190		49 _
_		50 G
191		51 P
192		52 S
193		53 L
194		54 Q
195		55 Q
196		56 H
197		57 C
198		58 E
199		59 A
200		60 H
223
••••••••••
αE VI c.l VII VIII x
61 L
224		62 H
225		63 S
226		64 Q
227		65 G
228		66 L
229		67 V
230		68 H
231		69 L
232		70 D
233		71 V
234		72 K
235		73 P
236		74 A
237		75 N
238		76 I
239		77 F
240		78 L
241		79 L
249		80 G
250
••
DFG a.l
81 D
251		82 F
252		83 G
253		84 L
254		85 L
255
•

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