KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	EGFR
Family:	EGFR
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	1797
PDB:	1M17
sc-PDB:
KIDFamMap:	Search
Release date:	2002-09-04
PubMed:	12196540
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	AQ4

More entries for 1M17
1M17	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	61° (18.9Å)
G-rich loop rotation:	35.8°
Quality Score:	8
Resolution:	2.6 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front gate back	BP-I-A BP-I-B	Cluster I6	Ligand Yes	Protein Yes

Pocket alignment
Uniprot sequence:	KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Sequence structure:	KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA

Ligand affinity
ChEMBL ID:	CHEMBL553
Bioaffinities:	397 records for 101 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Adaptor-associated kinase	5.9	5.4	5.9	pKd	3
Homo sapiens	ALK tyrosine kinase receptor	5.9	5.9	5.9	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.6	5.6	5.6	pKi	1
Homo sapiens	BMP-2-inducible protein kinase	5.9	5.8	5.9	pKd	3
Homo sapiens	CaM kinase II delta	5.2	5.2	5.2	pKd	1
Homo sapiens	Casein kinase I delta	5.5	5.5	5.5	pKd	2
Homo sapiens	Casein kinase I epsilon	6.3	6.3	6.3	pKd	1
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	5.7	5.7	5.7	pKd	2
Homo sapiens	Citron Rho-interacting kinase	6.2	6.2	6.2	pKd	2
Homo sapiens	c-Jun N-terminal kinase 2	5.4	5.4	5.7	pKd	2
Homo sapiens	c-Jun N-terminal kinase 3	5.4	5.4	5.4	pKd	1
Homo sapiens	Death-associated protein kinase 3	5.2	5.2	5.2	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7	7	7	pKd	1
Homo sapiens	Dual specificity protein kinase TTK	5.4	5.4	5.4	pKd	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	5.9	5.9	5.9	pKd	1
Homo sapiens	Ephrin type-A receptor 3	5.6	5.6	5.6	pKd	2
Homo sapiens	Ephrin type-A receptor 5	6.2	6.2	6.2	pKd	1
Homo sapiens	Ephrin type-A receptor 6	6	6	6.4	pKd	4
Homo sapiens	Ephrin type-A receptor 7	5.9	5.9	5.9	pKd	2
Homo sapiens	Ephrin type-A receptor 8	6	6	6	pKd	2
Homo sapiens	Ephrin type-B receptor 1	6	6	6	pKd	1
Homo sapiens	Ephrin type-B receptor 4	5.7	5.7	5.7	pKd	1
Homo sapiens	Epidermal growth factor receptor erbB1	7.5	5	9.7	pIC50	80
Homo sapiens	Epidermal growth factor receptor erbB1	9.1	6.7	9.5	pKd	24
Homo sapiens	Epidermal growth factor receptor erbB1	10	7.4	10	pKi	4
Homo sapiens	Epithelial discoidin domain-containing receptor 1	6.1	6.1	6.1	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	5.4	5.4	5.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Focal adhesion kinase 1	5.1	5.1	5.1	pIC50	1
Homo sapiens	G protein-coupled receptor kinase 4	5.1	5.1	5.1	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	5.4	5.4	6	pKd	4
Homo sapiens	Hepatocyte growth factor receptor	6	6	6	pKi	1
Homo sapiens	Homeodomain-interacting protein kinase 4	6	6	6	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 4	5.2	5.2	5.2	pKi	1
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	5.9	5.9	5.9	pKd	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.3	5.3	5.5	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	6.1	6.1	6.1	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	5.7	5.7	5.7	pKi	1
Homo sapiens	MAP kinase-interacting serine/threonine-protein kinase MNK1	6.2	6.2	6.2	pKd	2
Homo sapiens	MAP kinase signal-integrating kinase 2	5.8	5.8	6	pKd	2
Homo sapiens	MAP kinase signal-integrating kinase 2	5.9	5.9	5.9	pKi	1
Homo sapiens	Misshapen-like kinase 1	5.9	5.9	5.9	pKd	1
Homo sapiens	Misshapen-like kinase 1	5.3	5.3	5.3	pKi	1
Homo sapiens	Mitogen-activated protein kinase 4	5.6	5.6	5.6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	5.6	5.6	5.6	pKd	1
Homo sapiens	myosin light chain kinase 2	6	6	6	pKd	2
Homo sapiens	Myotonin-protein kinase	5.5	5.5	5.5	pKd	2
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	6.2	6.2	6.2	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	5.8	5.8	5.8	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	4.9	4.1	5.6	pIC50	7
Homo sapiens	Platelet-derived growth factor receptor beta	5.9	5.9	5.9	pKd	2
Homo sapiens	Protein kinase N2	5.6	5.6	5.6	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	6	6	6	pKd	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	5.3	5.3	5.3	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.5	4.7	7	pIC50	28
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.3	5.3	5.5	pKd	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	7.7	7.7	7.7	pKi	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6	6	6	pIC50	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6.6	6.6	6.6	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	5.9	5.9	5.9	pKi	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	8	8	8	pIC50	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	6	6	6	pKd	1
Homo sapiens	Ribosomal protein S6 kinase alpha 4	5.2	5.2	5.2	pKd	4
Homo sapiens	Serine/threonine-protein kinase 10	7.1	7.1	7.7	pKd	4
Homo sapiens	Serine/threonine-protein kinase 17A	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17B	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase 2	7.6	7	7.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase 2	7.3	7.3	7.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase 36	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.7	5.4	5.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase B-raf	7.2	7.2	7.2	pIC50	1
Mus musculus	Serine/threonine-protein kinase B-raf	7.2	7.2	7.2	pIC50	1
Homo sapiens	Serine/threonine-protein kinase D2	5.6	5.6	5.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase GAK	8.5	7.4	8.5	pKd	6
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIPK2	6.2	6.2	6.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase SBK1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase SRPK3	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	6	6	6	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.6	7.6	7.6	pKd	1
Homo sapiens	Stem cell growth factor receptor	5.8	5.5	5.9	pKd	9
Homo sapiens	TRAF2- and NCK-interacting kinase	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase ABL	5.7	5.7	5.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase ABL	6.6	5.1	7.2	pKd	30
Homo sapiens	Tyrosine-protein kinase ABL	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL2	6.7	6.5	6.7	pKd	3
Homo sapiens	Tyrosine-protein kinase BLK	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	6	6	6	pKi	1
Homo sapiens	Tyrosine-protein kinase CSK	5	5	5	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	6	6	6	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	5.7	5.7	5.7	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	6.5	6.5	6.5	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK2	5.4	5.4	5.4	pIC50	2
Homo sapiens	Tyrosine-protein kinase JAK2	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK3	6	6	6.2	pKd	4
Homo sapiens	Tyrosine-protein kinase LCK	6.3	6.3	6.6	pKd	4
Homo sapiens	Tyrosine-protein kinase Lyn	6.3	6.3	6.3	pKd	2
Homo sapiens	Tyrosine-protein kinase Lyn	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	6.3	5.9	6.9	pKd	10
Homo sapiens	Tyrosine-protein kinase receptor RET	5.9	5.9	6.5	pKd	4
Homo sapiens	Tyrosine-protein kinase receptor RET	5.8	5.8	5.8	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.4	5.4	5.4	pKd	1
Gallus gallus	Tyrosine-protein kinase SRC	4.8	4.8	6	pIC50	2
Homo sapiens	Tyrosine-protein kinase SRC	6.2	5.7	6.2	pKd	3
Homo sapiens	Tyrosine-protein kinase SYK	5.8	5.8	5.8	pKi	1
Homo sapiens	Tyrosine-protein kinase TXK	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase TYK2	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase YES	5.7	5.7	5.7	pKd	2
Mus musculus	ULK3 kinase	6.2	6.2	6.2	pKd	1
Homo sapiens	Uncharacterized aarF domain-containing protein kinase 4	5.6	5.6	5.6	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	5.8	5.8	5.8	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.9	6.1	7.3	pIC50	5
Homo sapiens	Vascular endothelial growth factor receptor 2	5.2	5.2	5.2	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	5.7	5.7	5.7	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 3	6.1	6.1	6.1	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 K
692

2 V
693

3 L
694

4 G
695

5 S
696

6 G
697

7 A
698

8 F
699

9 G
700

10 T
701

11 V
702

12 Y
703

13 K
704

14 V
718

15 A
719

16 I
720

17 K
721

18 E
722

19 L
723

20 E
734

•

αC

b.l

21 I
735

22 L
736

23 D
737

24 E
738

25 A
739

26 Y
740

27 V
741

28 M
742

29 A
743

30 S
744

31 V
745

32 D
746

33 P
748

34 H
749

35 V
750

36 C
751

37 R
752

38 L
753

39 L
754

40 G
755

hinge

linker

αD

αE

41 I
756

42 Q
763

43 L
764

44 I
765

45 T
766

46 Q
767

47 L
768

48 M
769

49 P
770

50 F
771

51 G
772

52 C
773

53 L
774

54 L
775

55 D
776

56 Y
777

57 V
778

58 R
779

59 E
780

60 Y
803

•

••

•

αE

c.l

VII

VIII

61 L
804

62 E
805

63 D
806

64 R
807

65 R
808

66 L
809

67 V
810

68 H
811

69 R
812

70 D
813

71 L
814

72 A
815

73 A
816

74 R
817

75 N
818

76 V
819

77 L
820

78 V
821

79 I
829

80 T
830

•

DFG

a.l

81 D
831

82 F
832

83 G
833

84 L
834

85 A
835

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: