Epidermal growth factor receptor
Kinase structure
Kinase:EGFR
Family:EGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1797
PDB:2JIT
sc-PDB:
KIDFamMap:Search
Release date:2008-01-22
PubMed: 18227510
Chain:A
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The orthosteric binding pocket


More entries for 2JIT
2JITChain: B


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):61.9° (18.3Å)
G-rich loop rotation:55°
Quality Score:8
Resolution:3.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I10
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLITQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA
Sequence structure:KVLGSGAFGTVYKVAIKELEILDEAYVMASVDPHVCRLLGIQLIMQLMPFGCLLDYVREYLEDRRLVHRDLAARNVLVITDFGLA