KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Kinase structure
Kinase:	PIK3CG (p110g)
Family:	PIK
Group:	Atypical
Species:	HUMAN
IUPHAR/BPS ID:	2156
PDB:	3DBS
sc-PDB:
KIDFamMap:	Search
Release date:	2008-06-17
PubMed:	18754654
Chain:	A
Orthosteric ligand:	GD9

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	58.4° (17.9Å)
G-rich loop rotation:	82.4°
Quality Score:	7.2
Resolution:	2.8 Å
Missing Residues:	1
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front gate	BP-I-A BP-I-B

Pocket alignment
Uniprot sequence:	CKVMASKKKPLWLIIFKHGDLRQDMLILQILRLCLLPYGCIIGMIEIVKATTIAKIQQSATFV--LGIGDRHNDNIMIHIDFGHI
Sequence structure:	CKVMASKKKPLWLIIFKHGDLRQDMLILQILRLCLLPYGCIIGMIEIVKATTIAKIQQSATFV__LGIGDRHNDNIMIHIDFGH_

Ligand affinity
ChEMBL ID:	CHEMBL521851
Bioaffinities:	67 records for 43 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Adaptor-associated kinase	5	5	5	pKd	1
Homo sapiens	CaM kinase I alpha	5.3	5.3	5.3	pKd	1
Homo sapiens	CaM kinase I gamma	5.2	5.2	5.2	pKd	1
Homo sapiens	Casein kinase I delta	5.9	5.9	5.9	pKd	1
Homo sapiens	Casein kinase I epsilon	5.9	5.9	5.9	pKd	1
Homo sapiens	Casein kinase II alpha (prime)	5.6	5.6	5.6	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	5.8	5.8	5.8	pKi	1
Homo sapiens	c-Jun N-terminal kinase 2	5.8	5.8	5.8	pKd	1
Homo sapiens	c-Jun N-terminal kinase 3	6.3	6.3	6.3	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	5.4	5.4	5.4	pKi	1
Homo sapiens	Death-associated protein kinase 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Death-associated protein kinase 3	5.8	5.8	5.8	pKd	1
Homo sapiens	DNA-dependent protein kinase	5.9	5.9	5.9	pIC50	1
Homo sapiens	DNA-dependent protein kinase	5.9	5.9	5.9	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	6.2	6.2	6.2	pKd	1
Homo sapiens	Dual specificity protein kinase CLK4	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity protein kinase CLK4	6	6	6	pKi	1
Homo sapiens	Dual specificity protein kinase TTK	5.4	5.4	5.4	pKd	1
Homo sapiens	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	5.4	5.4	5.4	pKd	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	5.1	5.1	5.1	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	6	6	6	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 1	6	6	6	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6.3	6.3	6.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	6.2	6.2	6.2	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 4	5.3	5.3	5.3	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 3	5.8	5.8	5.8	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.6	5.6	5.6	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	5.2	5.2	5.2	pKd	1
Homo sapiens	Myosin light chain kinase family member 4	6.1	6.1	6.1	pKd	1
Homo sapiens	Nerve growth factor receptor Trk-A	5.5	5.5	5.5	pIC50	1
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.5	5.5	5.5	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase 16	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase AKT	7.4	7.3	7.6	pIC50	3
Homo sapiens	Serine/threonine-protein kinase GAK	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase ICK	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase mTOR	6.4	6.2	6.9	pIC50	6
Homo sapiens	Serine/threonine-protein kinase mTOR	6.7	6.7	7.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase mTOR	6.2	6.2	6.2	pKi	3
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO2	6.2	6.2	6.2	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase JAK1	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5.6	5.4	6.2	pKd	6
Homo sapiens	Tyrosine-protein kinase TYK2	5.8	5.8	5.8	pKd	2

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 C
801

2 K
802

3 V
803

4 M
804

5 A
805

6 S
806

7 K
807

8 K
808

9 K
809

10 P
810

11 L
811

12 W
812

13 L
813

14 I
830

15 I
831

16 F
832

17 K
833

18 H
834

19 G
835

20 D
837

•

αC

b.l

21 L
838

22 R
839

23 Q
840

24 D
841

25 M
842

26 L
843

27 I
844

28 L
845

29 Q
846

30 I
847

31 L
848

32 R
849

33 L
862

34 C
863

35 L
864

36 L
865

37 P
866

38 Y
867

39 G
868

40 C
869

•

•••

hinge

linker

αD

αE

41 I
870

42 I
876

43 G
877

44 M
878

45 I
879

46 E
880

47 I
881

48 V
882

49 K
883

50 A
885

51 T
886

52 T
887

53 I
888

54 A
889

55 K
890

56 I
891

57 Q
892

58 Q
893

59 S
894

60 A
938

•

••

•

αE

c.l

VII

VIII

61 T
939

62 F
940

63 V
941

64 _
_

65 _
_

66 L
942

67 G
943

68 I
944

69 G
945

70 D
946

71 R
947

72 H
948

73 N
949

74 D
950

75 N
951

76 I
952

77 M
953

78 I
954

79 H
962

80 I
963

•

DFG

a.l

81 D
964

82 F
965

83 G
966

84 H
967

85 _
_

••

Interaction pattern search

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