SRC proto-oncogene, non-receptor tyrosine kinase
Kinase structure
Kinase:SRC
Family:Src
Group:TK
Species:HUMAN
IUPHAR/BPS ID:2206
PDB:1FMK
sc-PDB:
KIDFamMap:Search
Release date:1997-08-20
PubMed: 9024657
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):50.5° (15Å)
G-rich loop rotation:46°
Quality Score:8
Resolution:1.5 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I2
I4
I5
I6
I8
I9
I11
Ligand
No
No
No
No
No
No
No
No
Protein
Yes
Yes
No
Yes
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA
Sequence structure:VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA