Neurotrophic tyrosine kinase, receptor, type 1
Kinase structure
Kinase:NTRK1 (TRKA)
Family:Trk
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1817
PDB:6D22
sc-PDB:
KIDFamMap:Search
Release date:2018-05-02
PubMed: 29672039
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):61.7° (19.1Å)
G-rich loop rotation:49°
Quality Score:7.2
Resolution:2.46 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
I8
I9
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS
Sequence structure:WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS