PDB-code
Browse kinase entries (page 223 of 282)
First 219 220 221 PreviousLast227 226 225 Next| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | PIK3CA (p110a) | PIK | Atypical | 8tsc | A | - | Human | Show |  | |
| PIK3CA (p110a) | PIK | Atypical | 8tsd | A | - | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8tu6 | A | - | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8twy | A | n-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8v8h | A | (2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8v8i | A | (2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8v8j | A | (2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8v8u | A | (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8v8v | A | (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8w9a | A | - | Human | Show | | |
| PIK3CA (p110a) | PIK | Atypical | 8w9b | A | - | Human | Show | | |
| Pik3cb (p110b) | PIK | Atypical | 2y3a | A | 2-(1h-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | Mouse | Show | | |
| Pik3cb (p110b) | PIK | Atypical | 4bfr | A | 2-[2-(2-methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3h-pyrimidin-4-one | Mouse | Show | | |
| Pik3cb (p110b) | PIK | Atypical | 4bfr | B | 2-[2-(2-methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3h-pyrimidin-4-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxf | A | A | 2-((9h-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3h)-one | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxf | A | B | 2-((9h-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3h)-one | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxg | A | 2-{[4-amino-3-(3-fluoro-5-hydroxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxh | A | 2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxi | A | 2-{[4-amino-3-(3-hydroxyprop-1-yn-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxj | A | n-[6-(4-amino-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1h-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzothiazol-2-yl]acetamide | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxk | A | 3-(2-amino-1,3-benzothiazol-6-yl)-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxl | A | A | 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1h-benzimidazole | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxl | A | B | 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1h-benzimidazole | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxm | A | 1-(1-methylethyl)-3-(pyridin-3-ylethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxn | A | 3-{[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]ethynyl}phenol | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxo | A | A | n-(3-{[(1z)-3,5-dimethoxycyclohexa-2,4-dien-1-ylidene]amino}quinoxalin-2-yl)-4-fluorobenzenesulfonamide | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxo | A | B | n-(3-{[(1z)-3,5-dimethoxycyclohexa-2,4-dien-1-ylidene]amino}quinoxalin-2-yl)-4-fluorobenzenesulfonamide | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2wxp | A | 2-(1h-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxq | A | 2-{[3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl]sulfanyl}-n-quinoxalin-6-ylacetamide | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2wxr | A | - | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 2x38 | A | A | 2-[(6-amino-9h-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 2x38 | A | B | 2-[(6-amino-9h-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 4ajw | A | 2-[(1-methyl-1h-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 4ajw | B | 2-[(1-methyl-1h-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 4v0i | A | 2-[2-(2-methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3h-pyrimidin-4-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 4v0i | B | 2-[2-(2-methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3h-pyrimidin-4-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 4xe0 | A | 5-fluoro-3-phenyl-2-[(1s)-1-(7h-purin-6-ylamino)propyl]quinazolin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5ae8 | A | 6-(1h-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1h-indazole | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5ae9 | A | n-[5-[4-(5-{[(2r,6s)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1h-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5i4u | A | 2,4-diamino-6-{[(1s)-1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl]amino}pyrimidine-5-carbonitrile | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5i6u | A | 2-[(1s)-1-({6-amino-5-[(1h-pyrazol-4-yl)ethynyl]pyrimidin-4-yl}amino)ethyl]-5-chloro-3-phenylquinazolin-4(3h)-one | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5is5 | A | 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5l72 | A | n-[6-(5-methanesulfonamido-6-methoxypyridin-3-yl)-1,3-dihydro-2-benzofuran-4-yl]-2-(morpholin-4-yl)acetamide | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5ncy | A | A | 4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 5ncy | A | B | 4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 5ncz | A | A | 4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 5ncz | A | B | 4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile | Mouse | Show | |
| Pik3cd (p110d) | PIK | Atypical | 5ngb | A | 3-[[4-(2-morpholin-4-yl-4-oxidanylidene-3~{h}-quinolin-8-yl)-1,2,3-triazol-1-yl]methyl]benzoic acid | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5o83 | A | leniolisib | Mouse | Show | | |
| Pik3cd (p110d) | PIK | Atypical | 5t27 | A | 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{s})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine | Mouse | Show | |
