PDB-code
Browse kinase entries (page 272 of 282)
First 268 269 270 PreviousLast276 275 274 Next| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | TYK2 | JakA | TK | 4gih | A | A | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | Show |  |
| TYK2 | JakA | TK | 4gih | A | B | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | Show | |
| TYK2 | JakA | TK | 4gii | A | 2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | Show | | |
| TYK2 | JakA | TK | 4gj2 | A | 2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | Show | | |
| TYK2 | JakA | TK | 4gj3 | A | 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | Show | | |
| TYK2 | JakA | TK | 4gvj | A | adenosine-5'-diphosphate | Human | Show | | |
| TYK2 | JakA | TK | 4py1 | A | 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine | Human | Show | | |
| TYK2 | JakA | TK | 5f1z | A | A | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | Show | |
| TYK2 | JakA | TK | 5f1z | A | B | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | Show | |
| TYK2 | JakA | TK | 5f20 | A | 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | Show | | |
| TYK2 | JakA | TK | 5wal | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | Show | |
| TYK2 | JakA | TK | 5wal | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | Show | |
| TYK2 | JakA | TK | 6aam | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | Show | | |
| TYK2 | JakA | TK | 6dbk | A | 4-({4-[(1s,4s)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-n-ethylbenzamide | Human | Show | | |
| TYK2 | JakA | TK | 6dbm | A | A | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | Show | |
| TYK2 | JakA | TK | 6dbm | A | B | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | Show | |
| TYK2 | JakA | TK | 6ova | A | A | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 6ova | A | B | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 6vns | A | A | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 6vns | A | B | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 6vnv | A | (1s,2s)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | Show | | |
| TYK2 | JakA | TK | 6vnx | A | (1s)-2,2-difluoro-n-[(1s,5r,6r)-3-{5-fluoro-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | Show | | |
| TYK2 | JakA | TK | 6vny | A | n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | Human | Show | | |
| TYK2 | JakA | TK | 6x8f | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | Show | |
| TYK2 | JakA | TK | 6x8f | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | Show | |
| TYK2 | JakA | TK | 6x8f | C | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | Show | |
| TYK2 | JakA | TK | 6x8f | C | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | Show | |
| TYK2 | JakA | TK | 6x8g | A | A | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | Show | |
| TYK2 | JakA | TK | 6x8g | A | B | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | Show | |
| TYK2 | JakA | TK | 7uyr | A | A | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | Show | |
| TYK2 | JakA | TK | 7uyr | A | B | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | Show | |
| TYK2 | JakA | TK | 7uys | A | A | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | Show | |
| TYK2 | JakA | TK | 7uys | A | B | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | Show | |
| TYK2 | JakA | TK | 7uyt | A | A | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 7uyt | A | B | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | Show | |
| TYK2 | JakA | TK | 7uyu | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | Show | |
| TYK2 | JakA | TK | 7uyu | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | Show | |
| TYK2-b | JakB | TK | 3zon | A | 5-phenyl-2-ureidothiophene-3-carboxamide | Human | Show | | |
| TYK2-b | JakB | TK | 4oli | A | 2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | Show | | |
| TYK2-b | JakB | TK | 4wov | A | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | Show | |
| TYK2-b | JakB | TK | 4wov | A | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | Show | |
| TYK2-b | JakB | TK | 4wov | B | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | Show | |
| TYK2-b | JakB | TK | 4wov | B | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | Show | |
| TYK2-b | JakB | TK | 5c01 | A | unknown ligand | Human | Show | | |
| TYK2-b | JakB | TK | 5c01 | B | unknown ligand | Human | Show | | |
| TYK2-b | JakB | TK | 5c03 | A | A | phosphothiophosphoric acid-adenylate ester | Human | Show | |
| TYK2-b | JakB | TK | 5c03 | A | B | phosphothiophosphoric acid-adenylate ester | Human | Show | |
| TYK2-b | JakB | TK | 5c03 | B | A | phosphothiophosphoric acid-adenylate ester | Human | Show | |
| TYK2-b | JakB | TK | 5c03 | B | B | phosphothiophosphoric acid-adenylate ester | Human | Show | |
| TYK2-b | JakB | TK | 5tkd | A | A | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | Show | |
