Search results (100 entries covering 37 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	CLK1	CLK	CMGC	6g33	C	B	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	5j1w	B	B	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	5j1v	C		pyrido[3,4-g]quinazoline-2,10-diamine	Human	Show
	CLK1	CLK	CMGC	6g33	C	C	-	Human	Show
	CLK1	CLK	CMGC	6r3d	A		4-[6,7-bis(chloranyl)-1~{h}-indol-3-yl]pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	6ft8	A	A	3-(3-hydroxyphenyl)-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6g33	B	B	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	6raa	A	A	4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide	Human	Show
	CLK1	CLK	CMGC	6i5k	B	B	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6r8j	A	A	4-(1-methylindol-3-yl)pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	6z4z	B	B	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6qty	A	A	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	6tw2	E	B	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	6khd	A	B	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6khd	C	A	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6i5l	C	B	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6q8k	A	A	~{n}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine	Human	Show
	CLK1	CLK	CMGC	6i5h	A	A	5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6z4z	C	A	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6khd	B	A	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	7ak3	A	A	~{n}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	7opg	A	B	4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol	Human	Show
	CLK1	CLK	CMGC	5j1v	B		pyrido[3,4-g]quinazoline-2,10-diamine	Human	Show
	CLK1	CLK	CMGC	6r6e	A		5-[6,7-bis(chloranyl)-1-methyl-indol-3-yl]pyrimidin-4-amine	Human	Show
	CLK1	CLK	CMGC	1z57	A	A	debromohymenialdisine	Human	Show
	CLK1	CLK	CMGC	6i5k	C	A	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6i5l	C	A	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6i5k	B	A	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6z4z	C	B	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6i5l	B	B	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6z50	A	A	11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one	Human	Show
	CLK1	CLK	CMGC	6q8p	B		~{n}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	6ft9	A	B	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	8p04	A		(4~{z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{h}-imidazol-5-one	Human	Show
	CLK1	CLK	CMGC	8p08	A		(4~{z})-4-(1,3-benzothiazol-6-ylmethylidene)-2-[[(2~{r})-1-methoxy-4-methyl-pentan-2-yl]amino]-1~{h}-imidazol-5-one	Human	Show
	CLK1	CLK	CMGC	6khd	B	B	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6r6x	A		5-(1-methylindol-3-yl)pyrimidin-4-amine	Human	Show
	CLK1	CLK	CMGC	6r8j	A	B	4-(1-methylindol-3-yl)pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	6ytg	A	B	(4~{s})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	Human	Show
	CLK1	CLK	CMGC	6zln	A	B	4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-~{n}-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	6g33	B	A	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	6i5k	A	B	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6i5i	A	B	5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6khd	C	B	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	7o9y	A		4-(1~{h}-indol-3-yl)pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	1z57	A	B	debromohymenialdisine	Human	Show
	CLK1	CLK	CMGC	7opg	A	A	4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol	Human	Show
	CLK1	CLK	CMGC	6yti	A	A	methyl 9-[(2-fluoranyl-4-methoxy-phenyl)amino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	Human	Show
	CLK1	CLK	CMGC	5j1w	A	B	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	6i5h	A	B	5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6ft9	B	B	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6i5l	A	A	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6g33	C	A	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	6i5l	B	A	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6ft9	B	A	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6z50	A	B	11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one	Human	Show
	CLK1	CLK	CMGC	6yti	A	B	methyl 9-[(2-fluoranyl-4-methoxy-phenyl)amino]-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	Human	Show
	CLK1	CLK	CMGC	6g33	A	C	-	Human	Show
	CLK1	CLK	CMGC	5j1w	C	A	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	6ytg	A	A	(4~{s})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile	Human	Show
	CLK1	CLK	CMGC	5x8i	A		5-[1-[(1s)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole	Human	Show
	CLK1	CLK	CMGC	6z4z	B	A	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6fyo	A	B	6-~{tert}-butyl-~{n}-[6-(1~{h}-pyrazol-4-yl)-1~{h}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide	Human	Show
	CLK1	CLK	CMGC	6tw2	E	A	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	6i5l	A	B	3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6ytd	A	A	(1~{z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one	Human	Show
	CLK1	CLK	CMGC	6yte	C	A	(1~{z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one	Human	Show
	CLK1	CLK	CMGC	6g33	A	B	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	6ft9	C	B	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6g33	A	A	(2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol	Human	Show
	CLK1	CLK	CMGC	6z4z	A	B	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	2vag	A	A	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	6ytd	A	B	(1~{z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one	Human	Show
	CLK1	CLK	CMGC	6g33	B	C	-	Human	Show
	CLK1	CLK	CMGC	5j1w	C	B	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	5x8i	B		5-[1-[(1s)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole	Human	Show
	CLK1	CLK	CMGC	6fyo	A	A	6-~{tert}-butyl-~{n}-[6-(1~{h}-pyrazol-4-yl)-1~{h}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide	Human	Show
	CLK1	CLK	CMGC	6i5k	A	A	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	7oa0	A		5-[6,7-bis(chloranyl)-1-methyl-indol-3-yl]pyrimidin-4-amine	Human	Show
	CLK1	CLK	CMGC	6yte	C	B	(1~{z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one	Human	Show
	CLK1	CLK	CMGC	6i5k	C	B	5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6yta	A	B	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	Show
	CLK1	CLK	CMGC	6ft9	A	A	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6qty	A	B	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	5j1w	B	A	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	6ft8	A	B	3-(3-hydroxyphenyl)-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6khd	A	A	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6z4z	A	A	7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid	Human	Show
	CLK1	CLK	CMGC	6q8k	A	B	~{n}2-(3-morpholin-4-ylpropyl)pyrido[3,4-g]quinazoline-2,10-diamine	Human	Show
	CLK1	CLK	CMGC	6ft9	C	A	2-bromanyl-3-phenyl-1~{h}-pyrrolo[3,4-g]indol-8-one	Human	Show
	CLK1	CLK	CMGC	6i5i	A	A	5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine	Human	Show
	CLK1	CLK	CMGC	6q8p	A		~{n}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	7ak3	A	B	~{n}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	6raa	A	B	4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide	Human	Show
	CLK1	CLK	CMGC	6zln	A	A	4-(6-ethoxypyrazolo[1,5-b]pyridazin-3-yl)-~{n}-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine	Human	Show
	CLK1	CLK	CMGC	5j1w	A	A	pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	5j1v	A		pyrido[3,4-g]quinazoline-2,10-diamine	Human	Show
	CLK1	CLK	CMGC	6q8p	C		~{n}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine	Human	Show
	CLK1	CLK	CMGC	2vag	A	B	ethyl 3-[(e)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1h-indole-2-carboxylate	Human	Show
	CLK1	CLK	CMGC	6yta	A	A	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam