Search results (81 entries covering 33 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	ITK	Tec	TK	4qd6	B	A	trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4mf0	A		(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	3mj1	A		7-[(4-methylpiperazin-1-yl)methyl]-4-[(3-methyl-1h-pyrazol-5-yl)amino]-2-(tetrahydro-2h-pyran-4-yl)phthalazin-1(2h)-one	Human	Show
	ITK	Tec	TK	4rfm	A	B	(4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4ppc	B	A	n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4mf1	B	A	(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	3miy	A		n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	ITK	Tec	TK	3v5l	A		3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4kio	B	A	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one	Human	Show
	ITK	Tec	TK	3qgw	A	B	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	Show
	ITK	Tec	TK	4ppc	A	B	n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4l7s	B	B	trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4qd6	A	B	trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4mf1	B	B	(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	3t9t	A	B	(2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide	Human	Show
	ITK	Tec	TK	3qgy	B	A	n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide	Human	Show
	ITK	Tec	TK	4pqn	A	A	n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	1sm2	A		staurosporine	Human	Show
	ITK	Tec	TK	4kio	A	A	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one	Human	Show
	ITK	Tec	TK	4pp9	A		n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4m14	A		4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4kio	C	A	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one	Human	Show
	ITK	Tec	TK	4qd6	A	A	trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4rfm	A	A	(4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3v5j	B		3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4kio	D	B	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one	Human	Show
	ITK	Tec	TK	3v8w	B		3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4ppb	B		n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3t9t	A	A	(2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide	Human	Show
	ITK	Tec	TK	4kio	D	A	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one	Human	Show
	ITK	Tec	TK	4mf1	A	A	(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	4ppc	A	A	n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4ppb	A		n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3v8t	B	B	3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4kio	B	B	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one	Human	Show
	ITK	Tec	TK	3v8t	A	A	3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4kio	A	B	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one	Human	Show
	ITK	Tec	TK	3miy	B		n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	ITK	Tec	TK	3qgw	A	A	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	Show
	ITK	Tec	TK	3v5j	A		3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4kio	C	B	1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one	Human	Show
	ITK	Tec	TK	4ppa	B		n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3v8t	B	A	3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4m0z	A	A	4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3qgw	B	A	n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide	Human	Show
	ITK	Tec	TK	3v8t	A	B	3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol	Human	Show
	ITK	Tec	TK	4m12	A	A	-	Human	Show
	ITK	Tec	TK	4m0y	A	B	4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide	Human	Show
	ITK	Tec	TK	3qgy	B	B	n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide	Human	Show
	ITK	Tec	TK	4hcv	A		3-{4-amino-1-[(3s)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide	Human	Show
	ITK	Tec	TK	1snx	B		-	Human	Show
	ITK	Tec	TK	3qgy	A	A	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	Show
	ITK	Tec	TK	4m13	A	B	-	Human	Show
	ITK	Tec	TK	4l7s	A	B	trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4pqn	A	B	n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4l7s	B	A	trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	4mf1	A	B	(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	4l7s	A	A	trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	3v5l	C		3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4hct	A		3-{1-[(3r)-1-acryloylpiperidin-3-yl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-(3-tert-butylphenyl)benzamide	Human	Show
	ITK	Tec	TK	3v5l	B		3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4m15	A		adenosine-5'-diphosphate	Human	Show
	ITK	Tec	TK	3qgy	A	B	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	Show
	ITK	Tec	TK	4ppc	B	B	n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4m13	A	A	-	Human	Show
	ITK	Tec	TK	3qgw	B	B	n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide	Human	Show
	ITK	Tec	TK	1snu	A		staurosporine	Human	Show
	ITK	Tec	TK	4m0z	A	B	4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4m12	A	B	-	Human	Show
	ITK	Tec	TK	3mj2	A		n-[5-({5-[(4-acetylpiperazin-1-yl)carbonyl]-4-methoxy-2-methylphenyl}sulfanyl)-1,3-thiazol-2-yl]-4-({[(1s)-1,2,2-trimethylpropyl]amino}methyl)benzamide	Human	Show
	ITK	Tec	TK	3v5l	D		3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4pp9	B		n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	1snu	B		staurosporine	Human	Show
	ITK	Tec	TK	3v8w	A		3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol	Human	Show
	ITK	Tec	TK	4m0y	A	A	4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4mf0	B		(1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	Human	Show
	ITK	Tec	TK	4ppa	A		n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide	Human	Show
	ITK	Tec	TK	4qd6	B	B	trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol	Human	Show
	ITK	Tec	TK	1sm2	B		staurosporine	Human	Show
	ITK	Tec	TK	1snx	A		-	Human	Show
	ITK	Tec	TK	4hcu	A		3-{4-amino-1-[(3r)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam