Search results (54 entries covering 19 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	RIPK1	RIPK	TKL	4neu	A	B	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	Show
	RIPK1	RIPK	TKL	5tx5	A	A	gsk2982772	Human	Show
	RIPK1	RIPK	TKL	4itj	A	A	n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4itj	A	B	n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4neu	B	A	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	Show
	RIPK1	RIPK	TKL	6nw2	A	B	(5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6r5f	B		[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone	Human	Show
	RIPK1	RIPK	TKL	5tx5	A	B	gsk2982772	Human	Show
	RIPK1	RIPK	TKL	6ocq	A	A	1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one	Human	Show
	RIPK1	RIPK	TKL	6c3e	A	A	2-benzyl-5-nitro-1h-benzimidazole	Human	Show
	RIPK1	RIPK	TKL	7xmk	A		5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4ith	B	A	(5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione	Human	Show
	RIPK1	RIPK	TKL	4itj	B	B	n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6rln	B		~{n}-[(3~{s})-7,9-bis(fluoranyl)-2-oxidanylidene-1,3,4,5-tetrahydro-1-benzazepin-3-yl]-3-(phenylmethyl)-1~{h}-1,2,4-triazole-5-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4ith	A	B	(5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione	Human	Show
	RIPK1	RIPK	TKL	4iti	B	B	1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone	Human	Show
	RIPK1	RIPK	TKL	6r5f	C		[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone	Human	Show
	RIPK1	RIPK	TKL	6c4d	A		(3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	4iti	B	A	1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone	Human	Show
	RIPK1	RIPK	TKL	5tx5	B	A	gsk2982772	Human	Show
	RIPK1	RIPK	TKL	6ocq	B	B	1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one	Human	Show
	RIPK1	RIPK	TKL	4ith	B	B	(5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione	Human	Show
	RIPK1	RIPK	TKL	5hx6	B		5-benzyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6c4d	C		(3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	6nw2	A	A	(5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6c3e	B	A	2-benzyl-5-nitro-1h-benzimidazole	Human	Show
	RIPK1	RIPK	TKL	7fd0	A		n-[(3s)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4h-1,2,4-triazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	5hx6	A		5-benzyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6r5f	D		[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone	Human	Show
	RIPK1	RIPK	TKL	6c4d	D		(3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	6nw2	B	A	(5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6r5f	A		[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone	Human	Show
	RIPK1	RIPK	TKL	6hho	B		6-[4-[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	7ydx	A	B	1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-phenylethyl]indole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4neu	B	B	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	Show
	RIPK1	RIPK	TKL	4neu	A	A	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	Show
	RIPK1	RIPK	TKL	4iti	A	A	1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone	Human	Show
	RIPK1	RIPK	TKL	4iti	A	B	1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone	Human	Show
	RIPK1	RIPK	TKL	8i2n	A		~{n}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6ocq	B	A	1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one	Human	Show
	RIPK1	RIPK	TKL	5tx5	B	B	gsk2982772	Human	Show
	RIPK1	RIPK	TKL	6nyh	A		(5s)-n-[(3s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6rln	A		~{n}-[(3~{s})-7,9-bis(fluoranyl)-2-oxidanylidene-1,3,4,5-tetrahydro-1-benzazepin-3-yl]-3-(phenylmethyl)-1~{h}-1,2,4-triazole-5-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6c4d	B		(3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	4itj	B	A	n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	4ith	A	A	(5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione	Human	Show
	RIPK1	RIPK	TKL	6c3e	B	B	2-benzyl-5-nitro-1h-benzimidazole	Human	Show
	RIPK1	RIPK	TKL	6nw2	B	B	(5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6ocq	A	B	1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one	Human	Show
	RIPK1	RIPK	TKL	6hho	A		6-[4-[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile	Human	Show
	RIPK1	RIPK	TKL	7ydx	A	A	1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-phenylethyl]indole-3-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6nyh	B		(5s)-n-[(3s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide	Human	Show
	RIPK1	RIPK	TKL	6c3e	A	B	2-benzyl-5-nitro-1h-benzimidazole	Human	Show
	RIPK1	RIPK	TKL	7fcz	A		n-[(3s)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4h-1,2,4-triazole-3-carboxamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam