Insulin like growth factor 1 receptor
Kinase structure
Kinase:IGF1R
Family:InsR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1801
PDB:1P4O
sc-PDB:
KIDFamMap:Search
Release date:2003-04-29
PubMed: 14501110
Chain:A
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The orthosteric binding pocket


More entries for 1P4O
1P4OChain: B


Structural information
DFG conformation:out-like
αC-helix conformation:in
G-rich loop angle (distance):65.3° (19Å)
G-rich loop rotation:69.1°
Quality Score:7.6
Resolution:1.5 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I3
I6
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:RELGQGSFGMVYEVAIKTVEFLNEASVMKEFN-HVVRLLGVLVIMELMTRGDLKSYLRSYLNANKFVHRDLAARNCMVIGDFGMT
Sequence structure:RELGQGSFGMVYEVAIKTVEFLNEASVMKEFN_HVVRLLGVLVIMELMTRGDLKSYLRSYLNANKFVHRDLAARNCMVIGDFGMT