Search results (79 entries covering 28 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	IGF1R	InsR	TK	3d94	A	A	3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine	Human	Show
	IGF1R	InsR	TK	8pym	A		5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	5hzn	A		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	3d94	A	B	3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine	Human	Show
	IGF1R	InsR	TK	6jk8	A	A	-	Human	Show
	IGF1R	InsR	TK	8pyk	A	A	5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3qqu	D		n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine	Human	Show
	IGF1R	InsR	TK	5fxr	A	A	5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine	Human	Show
	IGF1R	InsR	TK	3lw0	B	A	-	Human	Show
	IGF1R	InsR	TK	5fxs	A	A	2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamide	Human	Show
	IGF1R	InsR	TK	2zm3	D		(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione	Human	Show
	IGF1R	InsR	TK	3f5p	F		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3qqu	B		n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine	Human	Show
	IGF1R	InsR	TK	3f5p	H		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	1m7n	A		-	Human	Show
	IGF1R	InsR	TK	8pyj	A		5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3o23	A		(5s)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3lvp	B		3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine	Human	Show
	IGF1R	InsR	TK	6jk8	B	A	-	Human	Show
	IGF1R	InsR	TK	6jk8	A	B	-	Human	Show
	IGF1R	InsR	TK	3lvp	D		3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine	Human	Show
	IGF1R	InsR	TK	5hzn	H		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	1jqh	C		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IGF1R	InsR	TK	3f5p	I		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	8pyn	A	A	5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	5hzn	E		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	3nw5	A		n-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2r)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine	Human	Show
	IGF1R	InsR	TK	3lvp	C		3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine	Human	Show
	IGF1R	InsR	TK	8pyi	A		3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol	Human	Show
	IGF1R	InsR	TK	1p4o	B		-	Human	Show
	IGF1R	InsR	TK	3lw0	C	A	-	Human	Show
	IGF1R	InsR	TK	3lvp	A		3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine	Human	Show
	IGF1R	InsR	TK	3lw0	A	A	-	Human	Show
	IGF1R	InsR	TK	3f5p	K		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	4d2r	A	B	n-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	Human	Show
	IGF1R	InsR	TK	1p4o	A		-	Human	Show
	IGF1R	InsR	TK	3f5p	C		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	5fxs	A	B	2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamide	Human	Show
	IGF1R	InsR	TK	3f5p	D		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	8pyk	A	B	5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3f5p	M		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3f5p	T		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3f5p	E		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	2zm3	B		(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione	Human	Show
	IGF1R	InsR	TK	3nw6	A		n-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2s)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine	Human	Show
	IGF1R	InsR	TK	4d2r	A	A	n-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	Human	Show
	IGF1R	InsR	TK	1k3a	A		phosphomethylphosphonic acid adenylate ester	Human	Show
	IGF1R	InsR	TK	3f5p	S		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3nw7	A		n-({4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide	Human	Show
	IGF1R	InsR	TK	3f5p	G		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	5hzn	C		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	3f5p	R		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3lw0	B	B	-	Human	Show
	IGF1R	InsR	TK	5hzn	D		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	2zm3	C		(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione	Human	Show
	IGF1R	InsR	TK	3qqu	C		n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine	Human	Show
	IGF1R	InsR	TK	5fxq	A		5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine	Human	Show
	IGF1R	InsR	TK	6jk8	B	B	-	Human	Show
	IGF1R	InsR	TK	1jqh	B		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IGF1R	InsR	TK	1jqh	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IGF1R	InsR	TK	2zm3	A		(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione	Human	Show
	IGF1R	InsR	TK	3lw0	C	B	-	Human	Show
	IGF1R	InsR	TK	2oj9	A		3-[5-(1h-imidazol-1-yl)-7-methyl-1h-benzimidazol-2-yl]-4-[(pyridin-2-ylmethyl)amino]pyridin-2(1h)-one	Human	Show
	IGF1R	InsR	TK	8pyn	A	B	5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3f5p	B		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	5hzn	B		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	3lw0	A	B	-	Human	Show
	IGF1R	InsR	TK	3f5p	L		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3f5p	A		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	3qqu	A		n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine	Human	Show
	IGF1R	InsR	TK	3lw0	D	A	-	Human	Show
	IGF1R	InsR	TK	5fxr	A	B	5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine	Human	Show
	IGF1R	InsR	TK	3lw0	D	B	-	Human	Show
	IGF1R	InsR	TK	8pyl	A		(5s)-5-methyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione	Human	Show
	IGF1R	InsR	TK	3i81	A		1-{4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-n-(6-fluoropyridin-3-yl)-2-methyl-l-prolinamide	Human	Show
	IGF1R	InsR	TK	5hzn	F		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IGF1R	InsR	TK	1m7n	B		-	Human	Show
	IGF1R	InsR	TK	3f5p	J		4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile	Human	Show
	IGF1R	InsR	TK	5hzn	G		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam