Version: 3.2
Updated: 29-Oct-2025
ABL proto-oncogene 1, non-receptor tyrosine kinase
Kinase structure
Kinase:ABL1
Family:Abl
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1923
PDB:2G1T
sc-PDB:
KIDFamMap:Search
Release date:2006-05-23
PubMed: 16640460
Chain:A
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The orthosteric binding pocket


More entries for 2G1T
2G1TChain: B
2G1TChain: C
2G1TChain: D


Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):51.3° (15.1Å)
G-rich loop rotation:49.9°
Quality Score:8
Resolution:1.8 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
I4
I5
I6
Ligand
No
No
No
No
Protein
Yes
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITEFMTYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS
Sequence structure:HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITEFMTYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS