Version: 3.2
Updated: 29-Oct-2025
Dual specificity tyrosine phosphorylation regulated kinase 1A
Kinase structure
Kinase:DYRK1A
Family:DYRK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:2009
PDB:6EIL
sc-PDB:
KIDFamMap:Search
Release date:2018-08-29
PubMed: 30095246
Chain:C
Click to open a 3D viewer
The orthosteric binding pocket


More entries for 6EIL
6EILChain: A
6EILChain: B
6EILChain: D


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):55.6° (17.4Å)
G-rich loop rotation:61.3°
Quality Score:8
Resolution:2.46 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:SLIGKGSFGQVVKVAIKIIQAQIEVRLLELMNYYIVHLKRHCLVFEMLS-YNLYDLLRNATPELSIIHCDLKPENILLIVDFGSS
Sequence structure:SLIGKGSFGQVVKVAIKIIQAQIEVRLLELMNYYIVHLKRHCLVFEMLS_YNLYDLLRNATPELSIIHCDLKPENILLIVDFGSS