PDB-code
| Kinase structure | |
| Kinase: | PRKG1 (PKG1) |
| Family: | PKG |
| Group: | AGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1492 |
| PDB: | 6BG2 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2018-10-31 |
| Chain: | C |
| (Alternate) Model: | A |
| Orthosteric ligand: | ANP |
 | |
| More entries for 6BG2 | |||||
| 6BG2 | Alternative model: | A | Chain: | A | |
| 6BG2 | Alternative model: | A | Chain: | B | |
| 6BG2 | Alternative model: | A | Chain: | D | |
| 6BG2 | Alternative model: | B | Chain: | A | |
| 6BG2 | Alternative model: | B | Chain: | B | |
| 6BG2 | Alternative model: | B | Chain: | C | |
| 6BG2 | Alternative model: | B | Chain: | D | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 50.7° (15.2Å) |
| G-rich loop rotation: | 54.6° |
| Quality Score: | 9.6 |
| Resolution: | 1.83 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 4 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I1 I4 | Ligand No No | Protein Yes Yes |
| Pocket alignment | |
| Uniprot sequence: | DTLGVGGFGRVELFAMKILHIRSEKQIMQGAHDFIVRLYRTYMLMEACLGGELWTILRDYLHSKGIIYRDLKPENLILLVDFGFA |
| Sequence structure: | DTLGVGGFGRVELFAMKILHIRSEKQIMQGAHDFIVRLYRTYMLMEACLGGELWTILRDYLHSKGIIYRDLKPENLILLVDFGFA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230989 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 D 364 | 2 T 365 | 3 L 366 | 4 G 367 | 5 V 368 | 6 G 369 | 7 G 370 | 8 F 371 | 9 G 372 | 10 R 373 | 11 V 374 | 12 E 375 | 13 L 376 | 14 F 387 | 15 A 388 | 16 M 389 | 17 K 390 | 18 I 391 | 19 L 392 | 20 H 405 |
| • | • | • | • | •• | • | • | • | • | |||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 406 | 22 R 407 | 23 S 408 | 24 E 409 | 25 K 410 | 26 Q 411 | 27 I 412 | 28 M 413 | 29 Q 414 | 30 G 415 | 31 A 416 | 32 H 417 | 33 D 419 | 34 F 420 | 35 I 421 | 36 V 422 | 37 R 423 | 38 L 424 | 39 Y 425 | 40 R 426 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 T 427 | 42 Y 435 | 43 M 436 | 44 L 437 | 45 M 438 | 46 E 439 | 47 A 440 | 48 C 441 | 49 L 442 | 50 G 443 | 51 G 444 | 52 E 445 | 53 L 446 | 54 W 447 | 55 T 448 | 56 I 449 | 57 L 450 | 58 R 451 | 59 D 452 | 60 Y 474 |
| • | • | •• | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 475 | 62 H 476 | 63 S 477 | 64 K 478 | 65 G 479 | 66 I 480 | 67 I 481 | 68 Y 482 | 69 R 483 | 70 D 484 | 71 L 485 | 72 K 486 | 73 P 487 | 74 E 488 | 75 N 489 | 76 L 490 | 77 I 491 | 78 L 492 | 79 L 500 | 80 V 501 |
| • | • | • | • | ||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 502 | 82 F 503 | 83 G 504 | 84 F 505 | 85 A 506 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
