PDB-code
| Kinase structure | |
| Kinase: | RET |
| Family: | Ret |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2185 |
| PDB: | 6NEC |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2019-06-05 |
| PubMed: | 31118272 |
| Chain: | C |
| (Alternate) Model: | A |
| Orthosteric ligand: | XIN |
 | |
| More entries for 6NEC | |||||
| 6NEC | Alternative model: | A | Chain: | A | |
| 6NEC | Alternative model: | B | Chain: | A | |
| 6NEC | Alternative model: | B | Chain: | C | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 56° (15.9Å) |
| G-rich loop rotation: | 80.8° |
| Quality Score: | 8 |
| Resolution: | 1.87 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front gate back | BP-I-B | Cluster I1 | Ligand No | Protein Yes |
| Pocket alignment | |
| Uniprot sequence: | KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS |
| Sequence structure: | KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL502835 |
| Bioaffinities: | 312 records for 219 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Activin receptor type-1B | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | CaM kinase I gamma | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM kinase IV | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Casein kinase I delta | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | cGMP-dependent protein kinase 1 beta | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 4 | 6.1 | 6.1 | 6.8 | pKd | 2 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 7.2 | 7 | 7.4 | pIC50 | 6 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.9 | 6.9 | 7 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.5 | 6.3 | 6.7 | pKd | 3 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase alpha subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Insulin receptor | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Insulin receptor-related protein | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.3 | 7.3 | 7.4 | pKd | 2 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 8.3 | 8.3 | 8.3 | pKi | 1 |
| Homo sapiens | Microtubule-associated serine/threonine-protein kinase 1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 15 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | myosin light chain kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase family member 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | NT-3 growth factor receptor | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.4 | 7.2 | 8.7 | pIC50 | 5 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8.5 | 7.2 | 8.7 | pIC50 | 5 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Protein kinase C mu | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Protein kinase C theta | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Protein kinase N1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Putative uncharacterized serine/threonine-protein kinase SgK110 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Rhodopsin kinase | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 6.8 | 6.8 | 6.8 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 7.2 | 7.2 | 7.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 7.2 | 7.2 | 7.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 5 | 6.7 | 6.7 | 6.7 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 6.6 | 6.6 | 6.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 11 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17B | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase D2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ICK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase OSR1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PRP4 homolog | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SBK1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Sgk3 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK3 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase WEE1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | STE20/SPS1-related proline-alanine-rich protein kinase | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 7.5 | 6.5 | 8.6 | pKd | 8 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | TGF-beta receptor type I | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 7.2 | 5.2 | 8 | pKd | 15 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 5.6 | 5.6 | 8.3 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7.9 | 7.9 | 7.9 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 8.1 | 8.1 | 8.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.8 | 7.8 | 7.8 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6.7 | 6.7 | 6.7 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 7.6 | 7.6 | 7.6 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.4 | 7.8 | 9.4 | pKd | 8 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 7.5 | 7.5 | 8 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.8 | 6.8 | 6.8 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 6.3 | 6.3 | 7.4 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase YES | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.5 | 7 | 7.6 | pIC50 | 3 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.1 | 7.7 | 8.5 | pIC50 | 6 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Mus musculus | Vascular endothelial growth factor receptor 2 | 7.9 | 7.9 | 7.9 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.3 | 7.9 | 8.5 | pIC50 | 4 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 7 | 7 | 7 | pKd | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 728 | 2 T 729 | 3 L 730 | 4 G 731 | 5 E 732 | 6 G 733 | 7 E 734 | 8 F 735 | 9 G 736 | 10 K 737 | 11 V 738 | 12 V 739 | 13 K 740 | 14 V 755 | 15 A 756 | 16 V 757 | 17 K 758 | 18 M 759 | 19 L 760 | 20 D 771 |
| • | • | • | • | • | • | • | •• | ||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 772 | 22 L 773 | 23 S 774 | 24 E 775 | 25 F 776 | 26 N 777 | 27 V 778 | 28 L 779 | 29 K 780 | 30 Q 781 | 31 V 782 | 32 N 783 | 33 P 785 | 34 H 786 | 35 V 787 | 36 I 788 | 37 K 789 | 38 L 790 | 39 Y 791 | 40 G 792 |
| • | • | • | |||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 793 | 42 L 801 | 43 L 802 | 44 I 803 | 45 V 804 | 46 E 805 | 47 Y 806 | 48 A 807 | 49 K 808 | 50 Y 809 | 51 G 810 | 52 S 811 | 53 L 812 | 54 R 813 | 55 G 814 | 56 F 815 | 57 L 816 | 58 R 817 | 59 E 818 | 60 Y 864 |
| • | • | • | •• | • | • | • | • | ||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 865 | 62 A 866 | 63 E 867 | 64 M 868 | 65 K 869 | 66 L 870 | 67 V 871 | 68 H 872 | 69 R 873 | 70 D 874 | 71 L 875 | 72 A 876 | 73 A 877 | 74 R 878 | 75 N 879 | 76 I 880 | 77 L 881 | 78 V 882 | 79 I 890 | 80 S 891 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 892 | 82 F 893 | 83 G 894 | 84 L 895 | 85 S 896 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
