Search results (58 entries covering 26 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	RET	Ret	TK	2x2l	A	C	(3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	5fm2	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	Show
	RET	Ret	TK	6vhg	A	A	3-(3,4-dimethoxyphenyl)-n~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine	Human	Show
	RET	Ret	TK	4cki	A	A	adenosine	Human	Show
	RET	Ret	TK	5fm3	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	Show
	RET	Ret	TK	7du9	A	A	pralsetinib	Human	Show
	RET	Ret	TK	2ivs	A	B	(3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide	Human	Show
	RET	Ret	TK	6nec	A	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	Show
	RET	Ret	TK	6ne7	A	A	adenosine monophosphate	Human	Show
	RET	Ret	TK	2x2m	A		(3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	7dua	A	C	4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide	Human	Show
	RET	Ret	TK	7ju6	A	A	selpercatinib	Human	Show
	RET	Ret	TK	6i82	B	B	~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine	Human	Show
	RET	Ret	TK	2ivt	A	B	adenosine monophosphate	Human	Show
	RET	Ret	TK	2x2m	B		(3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	6ne7	A	C	adenosine monophosphate	Human	Show
	RET	Ret	TK	7ju6	B	B	selpercatinib	Human	Show
	RET	Ret	TK	7ju5	B	A	pralsetinib	Human	Show
	RET	Ret	TK	6fek	A	A	adenosine	Human	Show
	RET	Ret	TK	7du8	A	B	selpercatinib	Human	Show
	RET	Ret	TK	4ckj	A	A	adenosine	Human	Show
	RET	Ret	TK	7nzn	A		2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{n}-(3-fluorophenyl)ethanamide	Human	Show
	RET	Ret	TK	4ckj	A	B	adenosine	Human	Show
	RET	Ret	TK	2ivs	A	A	(3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide	Human	Show
	RET	Ret	TK	6nec	A	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	Show
	RET	Ret	TK	6i82	B	A	~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine	Human	Show
	RET	Ret	TK	6nja	A	A	adenine	Human	Show
	RET	Ret	TK	2x2l	A	A	(3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	6i82	A	A	~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine	Human	Show
	RET	Ret	TK	7du9	A	B	pralsetinib	Human	Show
	RET	Ret	TK	6nja	A	B	adenine	Human	Show
	RET	Ret	TK	7ju5	A	A	pralsetinib	Human	Show
	RET	Ret	TK	2x2l	A	B	(3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	7dua	A	A	4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide	Human	Show
	RET	Ret	TK	6i83	A		4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide	Human	Show
	RET	Ret	TK	4cki	A	B	adenosine	Human	Show
	RET	Ret	TK	6i82	A	B	~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine	Human	Show
	RET	Ret	TK	2ivv	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	Show
	RET	Ret	TK	2x2k	A	B	(3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	7dua	A	B	4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide	Human	Show
	RET	Ret	TK	6nec	C	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	Show
	RET	Ret	TK	6fek	A	B	adenosine	Human	Show
	RET	Ret	TK	2x2k	A	A	(3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	RET	Ret	TK	7ju6	A	B	selpercatinib	Human	Show
	RET	Ret	TK	6nec	C	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	Show
	RET	Ret	TK	7du8	A	A	selpercatinib	Human	Show
	RET	Ret	TK	2ivs	B	A	(3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide	Human	Show
	RET	Ret	TK	7ju5	B	B	pralsetinib	Human	Show
	RET	Ret	TK	4cki	A	C	adenosine	Human	Show
	RET	Ret	TK	7ju5	A	B	pralsetinib	Human	Show
	RET	Ret	TK	7ju6	B	A	selpercatinib	Human	Show
	RET	Ret	TK	6vhg	A	B	3-(3,4-dimethoxyphenyl)-n~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine	Human	Show
	RET	Ret	TK	2ivu	A		4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline	Human	Show
	RET	Ret	TK	2ivt	A	A	adenosine monophosphate	Human	Show
	RET	Ret	TK	7run	A		1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one	Human	Show
	RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	Show
	RET	Ret	TK	2ivs	B	B	(3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide	Human	Show
	RET	Ret	TK	6ne7	A	B	adenosine monophosphate	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam