PDB-code
| Kinase structure | |
| Kinase: | FGFR4 |
| Family: | FGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1811 |
| PDB: | 6NVK |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2019-07-10 |
| PubMed: | 31413803 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | XL9 |
 | |
| More entries for 6NVK | |||||
| 6NVK | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | - |
| G-rich loop rotation: | - |
| Quality Score: | 6.7 |
| Resolution: | 2.3 Å |
| Missing Residues: | 4 |
| Missing Atoms: | 17 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front gate back | BP-I-A BP-I-B | |||
| Pocket alignment | |
| Uniprot sequence: | KPLGEGCFGQVVRVAVKMLDLVSEMEVMKLIGKNIINLLGVYVIVECAAKGNLREFLRAYLESRKCIHRDLAARNVLVIADFGLA |
| Sequence structure: | KPLGEG___QVVRVAVKMLDLVSEMEVMKLIGKNIINLLGVYVIVECAAKGNLREFLRAYLESRKCIHRDLAARNVLVIADFGL_ |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 471 | 2 P 472 | 3 L 473 | 4 G 474 | 5 E 475 | 6 G 476 | 7 _ _ | 8 _ _ | 9 _ _ | 10 Q 480 | 11 V 481 | 12 V 482 | 13 R 483 | 14 V 500 | 15 A 501 | 16 V 502 | 17 K 503 | 18 M 504 | 19 L 505 | 20 D 516 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 517 | 22 V 518 | 23 S 519 | 24 E 520 | 25 M 521 | 26 E 522 | 27 V 523 | 28 M 524 | 29 K 525 | 30 L 526 | 31 I 527 | 32 G 528 | 33 K 531 | 34 N 532 | 35 I 533 | 36 I 534 | 37 N 535 | 38 L 536 | 39 L 537 | 40 G 538 |
| • | • | • | |||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 539 | 42 Y 547 | 43 V 548 | 44 I 549 | 45 V 550 | 46 E 551 | 47 C 552 | 48 A 553 | 49 A 554 | 50 K 555 | 51 G 556 | 52 N 557 | 53 L 558 | 54 R 559 | 55 E 560 | 56 F 561 | 57 L 562 | 58 R 563 | 59 A 564 | 60 Y 593 |
| • | • | • | • | ••• | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 594 | 62 E 595 | 63 S 596 | 64 R 597 | 65 K 598 | 66 C 599 | 67 I 600 | 68 H 601 | 69 R 602 | 70 D 603 | 71 L 604 | 72 A 605 | 73 A 606 | 74 R 607 | 75 N 608 | 76 V 609 | 77 L 610 | 78 V 611 | 79 I 619 | 80 A 620 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 621 | 82 F 622 | 83 G 623 | 84 L 624 | 85 _ _ | |||||||||||||||
| •• | • | ||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
