Search results (58 entries covering 45 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	FGFR4	FGFR	TK	6nvh	A	A	n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	5jkg	A		2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol	Human	Show
	FGFR4	FGFR	TK	7ybp	A		~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide	Human	Show
	FGFR4	FGFR	TK	6jpj	A		n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	7wct	A		~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	6nvi	A	B	n-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	4tyg	A	B	-	Human	Show
	FGFR4	FGFR	TK	4xcu	A	A	n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	4tyi	A		4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	Show
	FGFR4	FGFR	TK	6v9c	A	A	n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	5xff	A		2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol	Human	Show
	FGFR4	FGFR	TK	5nwz	A		~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide	Human	Show
	FGFR4	FGFR	TK	7ybo	A		~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide	Human	Show
	FGFR4	FGFR	TK	6nvk	A	B	n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide	Human	Show
	FGFR4	FGFR	TK	4qqc	A	B	n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide	Human	Show
	FGFR4	FGFR	TK	4qqt	A		-	Human	Show
	FGFR4	FGFR	TK	4qqj	A		-	Human	Show
	FGFR4	FGFR	TK	6jpe	A		n-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	5nud	B		3-chloranyl-~{n}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine	Human	Show
	FGFR4	FGFR	TK	7yc3	A		6-bromanyl-~{n}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide	Human	Show
	FGFR4	FGFR	TK	4tyg	A	A	-	Human	Show
	FGFR4	FGFR	TK	7vjl	A		n-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	4qqc	A	A	n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide	Human	Show
	FGFR4	FGFR	TK	6iup	A	B	n-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	6yi8	A	B	n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	6yi8	B	A	n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	6yi8	B	B	n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	6nvj	A		n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-fluorophenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	5nud	A		3-chloranyl-~{n}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine	Human	Show
	FGFR4	FGFR	TK	6nvi	A	A	n-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	4r6v	A		n-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	4tye	A		-	Human	Show
	FGFR4	FGFR	TK	6nvk	A	A	n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide	Human	Show
	FGFR4	FGFR	TK	4uxq	A		3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	FGFR4	FGFR	TK	5nwz	B		~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide	Human	Show
	FGFR4	FGFR	TK	4xcu	A	B	n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	7dtz	A		n-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	6iuo	A		n-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	7v29	A		n-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4h-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	4qrc	A		3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	FGFR4	FGFR	TK	6v9c	A	B	n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	6nvg	A		n-[3,5-dichloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	7wcw	A		~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	6yi8	A	A	n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide	Human	Show
	FGFR4	FGFR	TK	7f3m	A		6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one	Human	Show
	FGFR4	FGFR	TK	7wcx	A		~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	6iup	A	A	n-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide	Human	Show
	FGFR4	FGFR	TK	4qq5	A		n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide	Human	Show
	FGFR4	FGFR	TK	7ybx	A		~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide	Human	Show
	FGFR4	FGFR	TK	8kh6	A		-	Human	Show
	FGFR4	FGFR	TK	8w5c	A		-	Human	Show
	FGFR4	FGFR	TK	8kh9	A		-	Human	Show
	FGFR4	FGFR	TK	8kh7	A		-	Human	Show
	FGFR4	FGFR	TK	7yc1	A		~{n}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-propyl-pyrrolo[3,2-b]pyridine-3-carboxamide	Human	Show
	FGFR4	FGFR	TK	4tyj	A		3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	FGFR4	FGFR	TK	6nvh	A	B	n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide	Human	Show
	FGFR4	FGFR	TK	5xfj	A		2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol	Human	Show
	FGFR4	FGFR	TK	8kh8	A		-	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam