PDB-code
| Kinase structure | |
| Kinase: | MET |
| Family: | Met |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1815 |
| PDB: | 6SD9 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2019-08-14 |
| PubMed: | 31531204 |
| Chain: | A |
| Orthosteric ligand: | 88Z |
 | |
| Structural information | |
| DFG conformation: | out |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 59.5° (18.6Å) |
| G-rich loop rotation: | 35.4° |
| Quality Score: | 8 |
| Resolution: | 2.35 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front gate back | BP-I-B BP-II-out BP-III | Cluster I1 | Ligand No | Protein Yes |
| Pocket alignment | |
| Uniprot sequence: | EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFGLA |
| Sequence structure: | EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1230609 |
| Bioaffinities: | 335 records for 188 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | ALK tyrosine kinase receptor | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Cell division cycle 2-like protein kinase 6 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Cell division protein kinase 8 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Citron Rho-interacting kinase | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 5 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 8.6 | 8.6 | 8.6 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 5 | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 8.6 | 8.6 | 8.6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 8 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 3 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.5 | 5.5 | 5.5 | pIC50 | 3 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 6.5 | 5.8 | 7.1 | pKd | 12 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 9.7 | 9.7 | 9.7 | pKd | 2 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 5.8 | 5.8 | 6 | pKd | 2 |
| Homo sapiens | Focal adhesion kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 8.8 | 7.7 | 9.4 | pIC50 | 43 |
| Homo sapiens | Hepatocyte growth factor receptor | 9 | 8.9 | 9.1 | pKd | 3 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Hormonally up-regulated neu tumor-associated kinase | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase alpha subunit | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Insulin receptor | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Insulin receptor-related protein | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | LIM domain kinase 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 8.5 | 8.5 | 8.5 | pIC50 | 6 |
| Homo sapiens | Macrophage-stimulating protein receptor | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | MAP kinase-interacting serine/threonine-protein kinase MNK1 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | MAP kinase p38 alpha | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | MAP kinase p38 beta | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | MAP kinase p38 delta | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | MAP kinase p38 gamma | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 6.5 | 6.5 | 6.5 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Mixed lineage kinase 7 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Myosin IIIA | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | myosin light chain kinase 2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | NT-3 growth factor receptor | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.4 | 8.2 | 8.4 | pIC50 | 3 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8 | 8 | 8 | pIC50 | 2 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 9.6 | 9.6 | 9.6 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 7.8 | 7.7 | 8.1 | pKi | 3 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 5.3 | 5.3 | 5.3 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 36 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 5.9 | 5.8 | 6.4 | pKd | 3 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase B-raf | 5.5 | 5.5 | 5.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MAK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK-A | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK beta | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK gamma | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK9 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine protein kinase NLK | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RAF | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 8.2 | 8.2 | 8.4 | pIC50 | 6 |
| Homo sapiens | Stem cell growth factor receptor | 8.5 | 7.4 | 8.7 | pKd | 8 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 7.4 | 6.5 | 8.4 | pKd | 15 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 5.8 | 5.8 | 5.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.3 | 8.3 | 8.4 | pIC50 | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.8 | 8 | 9.1 | pKd | 8 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8.8 | 8.6 | 9.2 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 9.1 | 9.1 | 9.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 10 | 10 | 10 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Srms | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 9 | 9 | 9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.3 | 5.3 | 5.3 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase YES | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 8.2 | 8.2 | 9.1 | pIC50 | 3 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 9.1 | 7.8 | 9.1 | pIC50 | 14 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.6 | 8.6 | 8.6 | pIC50 | 3 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.8 | 8.8 | 8.8 | pKd | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 1082 | 2 V 1083 | 3 I 1084 | 4 G 1085 | 5 R 1086 | 6 G 1087 | 7 H 1088 | 8 F 1089 | 9 G 1090 | 10 C 1091 | 11 V 1092 | 12 Y 1093 | 13 H 1094 | 14 C 1107 | 15 A 1108 | 16 V 1109 | 17 K 1110 | 18 S 1111 | 19 L 1112 | 20 Q 1123 |
| • | • | • | •• | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 1124 | 22 L 1125 | 23 T 1126 | 24 E 1127 | 25 G 1128 | 26 I 1129 | 27 I 1130 | 28 M 1131 | 29 K 1132 | 30 D 1133 | 31 F 1134 | 32 S 1135 | 33 P 1137 | 34 N 1138 | 35 V 1139 | 36 L 1140 | 37 S 1141 | 38 L 1142 | 39 L 1143 | 40 G 1144 |
| • | • | • | •• | • | • | ||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 1145 | 42 L 1154 | 43 V 1155 | 44 V 1156 | 45 L 1157 | 46 P 1158 | 47 Y 1159 | 48 M 1160 | 49 K 1161 | 50 H 1162 | 51 G 1163 | 52 D 1164 | 53 L 1165 | 54 R 1166 | 55 N 1167 | 56 F 1168 | 57 I 1169 | 58 R 1170 | 59 N 1171 | 60 Y 1194 |
| • | • | • | •• | • | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 1195 | 62 A 1196 | 63 S 1197 | 64 K 1198 | 65 K 1199 | 66 F 1200 | 67 V 1201 | 68 H 1202 | 69 R 1203 | 70 D 1204 | 71 L 1205 | 72 A 1206 | 73 A 1207 | 74 R 1208 | 75 N 1209 | 76 C 1210 | 77 M 1211 | 78 L 1212 | 79 V 1220 | 80 A 1221 |
| • | •• | •• | • | • | • | ||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1222 | 82 F 1223 | 83 G 1224 | 84 L 1225 | 85 A 1226 | |||||||||||||||
| •• | •• | • | |||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
