Search results (164 entries covering 100 PDB structures)

Your browser unfortunately does not support an HTML5 canvas. Your browser unfortunately does not support an HTML5 canvas.

#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	MET	Met	TK	8k78	A	A	-	Human	Show
	MET	Met	TK	8k78	A	B	-	Human	Show
	MET	Met	TK	7v3r	A	B	~{n}1'-[3-fluoranyl-4-(2-phenylazanylpyrimidin-4-yl)oxy-phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	7v3s	A	A	~{n}1'-[3-fluoranyl-4-(10~{h}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	7v3s	A	B	~{n}1'-[3-fluoranyl-4-(10~{h}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	7v3r	A	A	~{n}1'-[3-fluoranyl-4-(2-phenylazanylpyrimidin-4-yl)oxy-phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	8gvj	A		(1^4z,5^2e)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1h-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione	Human	Show
	MET	Met	TK	7y4u	A		~{n}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide	Human	Show
	MET	Met	TK	7y4t	A		2-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-(3-nitrophenyl)pyridazin-3-one	Human	Show
	MET	Met	TK	8ouu	A	B	5-(3-ethynyl-5-fluoranyl-1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8ouu	A	A	5-(3-ethynyl-5-fluoranyl-1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	7b3w	A	B	3-(6-fluoranyl-1~{h}-indazol-4-yl)-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	3dkf	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	3qti	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	Show
	MET	Met	TK	6sdc	A	A	n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3f66	B	B	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	5eyc	A	A	6-[(1~{r})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one	Human	Show
	MET	Met	TK	5dg5	B	B	n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	4knb	A	B	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	3qti	B	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	Show
	MET	Met	TK	5hor	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	Show
	MET	Met	TK	5eyd	A	B	6-[(1~{r})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one	Human	Show
	MET	Met	TK	5uab	A	B	n-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide	Human	Show
	MET	Met	TK	3dkg	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	4mxc	A	B	n-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	2wd1	A	B	1-[(2-nitrophenyl)sulfonyl]-1h-pyrrolo[3,2-b]pyridine-6-carboxamide	Human	Show
	MET	Met	TK	8an8	A		3-[bis(fluoranyl)methyl]-~{n}-methyl-~{n}-[(1~{r})-8-methyl-5-(3-methyl-1~{h}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide	Human	Show
	MET	Met	TK	8ans	A		3-[bis(fluoranyl)methyl]-~{n}-methyl-~{n}-[(1~{r})-8-methyl-5-(3-methyl-1~{h}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide	Human	Show
	MET	Met	TK	8aw1	A	B	3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	8aw1	A	A	3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	8au3	A		3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	8au5	A		3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	8ouv	A	A	5-(1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8owg	A		5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8ow3	A		5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8ouv	A	B	5-(1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8ov7	A		5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-[3-(1h-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	8ovz	A		1-[(1s)-1-[3-(1h-imidazol-4-yl)phenyl]ethyl]-5-(1h-indazol-7-yl)pyrimidine-2,4-dione	Human	Show
	MET	Met	TK	4knb	B	A	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	6sde	A		volitinib	Human	Show
	MET	Met	TK	4xyf	A	A	6-{(1s)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline	Human	Show
	MET	Met	TK	7b43	A		3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	4r1v	A	A	3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	4deh	A		5-phenyl-3-(quinolin-6-ylmethyl)-3,5,6,7-tetrahydro-4h-[1,2,3]triazolo[4,5-c]pyridin-4-one	Human	Show
	MET	Met	TK	7b42	A		3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	4r1y	A		3-(diethylamino)propyl (3-{[5-(3,4-dimethoxyphenyl)-2-oxo-2h-1,3,4-thiadiazin-3(6h)-yl]methyl}phenyl)carbamate	Human	Show
	MET	Met	TK	7b3t	A	B	3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	7b3v	A	B	3-(3-methyl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	3u6h	A	B	n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	Show
	MET	Met	TK	3a4p	A		(2e)-3-{6-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-n-methylprop-2-enamide	Human	Show
	MET	Met	TK	4knb	B	B	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	2wgj	A		3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	MET	Met	TK	5hti	A	B	n-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3zc5	A		6-{(1s)-1-[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline	Human	Show
	MET	Met	TK	4gg7	A	A	n-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine	Human	Show
	MET	Met	TK	3u6h	A	A	n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	Show
	MET	Met	TK	5dg5	A	A	n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3u6i	A		n-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-[(2r)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	Show
	MET	Met	TK	3cth	A		n-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide	Human	Show
	MET	Met	TK	3f66	B	D	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	9c1r	A	A	n-(2,5-difluoro-4-{[(1s,3s)-3-(1-methyl-1h-pyrazol-3-yl)cyclobutyl][(8r)-pyrazolo[1,5-a]pyrazin-4-yl]amino}phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide	Human	Show
	MET	Met	TK	9c1r	A	B	n-(2,5-difluoro-4-{[(1s,3s)-3-(1-methyl-1h-pyrazol-3-yl)cyclobutyl][(8r)-pyrazolo[1,5-a]pyrazin-4-yl]amino}phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide	Human	Show
	MET	Met	TK	3efj	B		2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	3ctj	A	A	2-(4-fluorophenyl)-n-{[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide	Human	Show
	MET	Met	TK	7b3q	A	A	1-(phenylmethyl)-5~{h}-pyrrolo[3,2-c]pyridin-4-one	Human	Show
	MET	Met	TK	3lq8	A	A	n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	5dg5	B	A	n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3lq8	A	B	n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3cd8	A	B	7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline	Human	Show
	MET	Met	TK	4eev	A	A	n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	MET	Met	TK	3f66	A	A	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	5eob	A	A	6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	Show
	MET	Met	TK	3f66	B	A	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	7b44	A	B	5-methoxy-1~{h}-indazole	Human	Show
	MET	Met	TK	3l8v	A		2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-n-(2,4-difluorophenyl)pyridine-3-carboxamide	Human	Show
	MET	Met	TK	5hni	X		methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate	Human	Show
	MET	Met	TK	4knb	C	A	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	6sdd	A		n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	MET	Met	TK	3zbx	A		6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	Show
	MET	Met	TK	5eyd	A	A	6-[(1~{r})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one	Human	Show
	MET	Met	TK	5ya5	A	A	2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1h-indole	Human	Show
	MET	Met	TK	4gg5	A	B	3-(4-methylpiperazin-1-yl)-n-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine	Human	Show
	MET	Met	TK	3f66	A	B	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	2rfn	B		2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	4aoi	A		4-[3-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzenecarbonitrile	Human	Show
	MET	Met	TK	7b3w	A	A	3-(6-fluoranyl-1~{h}-indazol-4-yl)-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	2wd1	A	A	1-[(2-nitrophenyl)sulfonyl]-1h-pyrrolo[3,2-b]pyridine-6-carboxamide	Human	Show
	MET	Met	TK	4deg	A		7-methoxy-n-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine	Human	Show
	MET	Met	TK	7b3z	A	A	3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	7b3q	A	B	1-(phenylmethyl)-5~{h}-pyrrolo[3,2-c]pyridin-4-one	Human	Show
	MET	Met	TK	6ubw	A		n-(6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide	Human	Show
	MET	Met	TK	4gg7	A	B	n-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine	Human	Show
	MET	Met	TK	7b3t	A	A	3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	7b41	A	A	3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	3zcl	A		(s)-3-(1-(1h-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-n-isopropyl-(1,2,4)triazolo(4,3-b)pyridazin-6-amine	Human	Show
	MET	Met	TK	5uab	A	A	n-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide	Human	Show
	MET	Met	TK	5eob	A	B	6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	Show
	MET	Met	TK	3f66	B	C	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	3dkf	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	4r1v	A	B	3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile	Human	Show
	MET	Met	TK	6sd9	A		n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	1r0p	A		k-252a	Human	Show
	MET	Met	TK	3qti	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	Show
	MET	Met	TK	4gg5	A	A	3-(4-methylpiperazin-1-yl)-n-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine	Human	Show
	MET	Met	TK	3dkf	A	C	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	5hni	Y		methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate	Human	Show
	MET	Met	TK	5hoa	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	Show
	MET	Met	TK	4knb	C	B	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	5hti	A	A	n-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	7b44	A	A	5-methoxy-1~{h}-indazole	Human	Show
	MET	Met	TK	3ce3	A		1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	MET	Met	TK	4eev	A	B	n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	MET	Met	TK	3dkc	A	A	adenosine-5'-triphosphate	Human	Show
	MET	Met	TK	3vw8	A		n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide	Human	Show
	MET	Met	TK	3q6w	A		3-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-n-(pyridin-2-ylmethyl)propanamide	Human	Show
	MET	Met	TK	7b3z	A	B	3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	4xyf	A	B	6-{(1s)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline	Human	Show
	MET	Met	TK	7b43	B		3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	3q6u	A	A	-	Human	Show
	MET	Met	TK	1r1w	A		-	Human	Show
	MET	Met	TK	7b3v	A	A	3-(3-methyl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	Show
	MET	Met	TK	3f66	A	C	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	5eyc	A	B	6-[(1~{r})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one	Human	Show
	MET	Met	TK	3rhk	B		1-[(3r,4r)-4-(1h-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium	Human	Show
	MET	Met	TK	3dkg	A	C	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	5uad	A		n-(6-{[6-(1-methyl-1h-pyrazol-4-yl)-1h-benzotriazol-1-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide	Human	Show
	MET	Met	TK	4knb	D	B	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	3ccn	A		4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol	Human	Show
	MET	Met	TK	2rfn	A		2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	3zxz	A		2-{4-[1-(quinolin-6-ylmethyl)-1h-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1h-pyrazol-1-yl}ethanol	Human	Show
	MET	Met	TK	5hlw	A		1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea	Human	Show
	MET	Met	TK	4ap7	A		4-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]phenol	Human	Show
	MET	Met	TK	2g15	A		-	Human	Show
	MET	Met	TK	4knb	A	A	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	4mxc	A	A	n-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	3f82	A		n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	MET	Met	TK	3q6u	A	B	-	Human	Show
	MET	Met	TK	3zze	A		(2s)-n'-[(3r)-4-chloro-7-methyl-2-oxo-2,3-dihydro-1h-indol-3-yl]-2-(4-hydroxyphenyl)propanehydrazide	Human	Show
	MET	Met	TK	3dkc	A	B	adenosine-5'-triphosphate	Human	Show
	MET	Met	TK	3f66	A	D	3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol	Human	Show
	MET	Met	TK	3qti	B	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	Show
	MET	Met	TK	5t3q	A		n-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	Show
	MET	Met	TK	5ho6	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	Show
	MET	Met	TK	3efk	B		5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	3i5n	A		7-methoxy-n-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine	Human	Show
	MET	Met	TK	3efj	A		2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	3r7o	A		n-[(2r)-1,4-dioxan-2-ylmethyl]-n-methyl-n'-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide	Human	Show
	MET	Met	TK	3dkg	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	Show
	MET	Met	TK	3efk	A		5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one	Human	Show
	MET	Met	TK	5dg5	A	B	n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	2rfs	A		n-(3-chlorophenyl)-n-methyl-2-oxo-3-[(3,4,5-trimethyl-1h-pyrrol-2-yl)methyl]-2h-indole-5-sulfonamide	Human	Show
	MET	Met	TK	3cd8	A	A	7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline	Human	Show
	MET	Met	TK	3rhk	A		1-[(3r,4r)-4-(1h-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium	Human	Show
	MET	Met	TK	4iwd	A		1-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-n-(pyridin-2-ylmethyl)methanesulfonamide	Human	Show
	MET	Met	TK	3c1x	A		n-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide	Human	Show
	MET	Met	TK	2wkm	A		(3z)-5-[(2,6-dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	Show
	MET	Met	TK	6sdc	A	B	n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	Human	Show
	MET	Met	TK	7b40	A		3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show
	MET	Met	TK	4dei	A		3-{(1s)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl}-5-(3-methyl-1,2-thiazol-5-yl)-3,5-dihydro-4h-[1,2,3]triazolo[4,5-c]pyridin-4-one	Human	Show
	MET	Met	TK	4knb	D	A	7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine	Human	Show
	MET	Met	TK	4xmo	A		6-{(1r)-1-fluoro-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-methoxyquinoline	Human	Show
	MET	Met	TK	5ya5	A	B	2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1h-indole	Human	Show
	MET	Met	TK	3ctj	A	B	2-(4-fluorophenyl)-n-{[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide	Human	Show
	MET	Met	TK	7b41	A	B	3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam