PDB-code
| Kinase structure | |
| Kinase: | PRPF4B (PRP4) |
| Family: | DYRK |
| Group: | CMGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2177 |
| PDB: | 6PK6 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2019-08-28 |
| Chain: | A |
| (Alternate) Model: | B |
| Orthosteric ligand: | OND |
 | |
| More entries for 6PK6 | |||||
| 6PK6 | Alternative model: | A | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 52° (16.3Å) |
| G-rich loop rotation: | 47.7° |
| Quality Score: | 9.6 |
| Resolution: | 2.1 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 4 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I5 | Ligand No | Protein Yes | |
| Pocket alignment | |
| Uniprot sequence: | GYTGQGVFSNVVRVAVKIITGLKELEFLKKLNFHCLRLFRHCLVFEPLS-MNLREVLKKLLKRCNILHADIKPDNILVLCDFGSA |
| Sequence structure: | GYTGQGVFSNVVRVAVKIITGLKELEFLKKLNFHCLRLFRHCLVFEPLS_MNLREVLKKLLKRCNILHADIKPDNILVLCDFGSA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 G 691 | 2 Y 692 | 3 T 693 | 4 G 694 | 5 Q 695 | 6 G 696 | 7 V 697 | 8 F 698 | 9 S 699 | 10 N 700 | 11 V 701 | 12 V 702 | 13 R 703 | 14 V 714 | 15 A 715 | 16 V 716 | 17 K 717 | 18 I 718 | 19 I 719 | 20 T 728 |
| • | • | • | • | • | •• | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 G 729 | 22 L 730 | 23 K 731 | 24 E 732 | 25 L 733 | 26 E 734 | 27 F 735 | 28 L 736 | 29 K 737 | 30 K 738 | 31 L 739 | 32 N 740 | 33 F 748 | 34 H 749 | 35 C 750 | 36 L 751 | 37 R 752 | 38 L 753 | 39 F 754 | 40 R 755 |
| • | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 H 756 | 42 C 764 | 43 L 765 | 44 V 766 | 45 F 767 | 46 E 768 | 47 P 769 | 48 L 770 | 49 S 771 | 50 _ _ | 51 M 772 | 52 N 773 | 53 L 774 | 54 R 775 | 55 E 776 | 56 V 777 | 57 L 778 | 58 K 779 | 59 K 780 | 60 L 805 |
| •• | • | • | • | • | •• | ||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 806 | 62 K 807 | 63 R 808 | 64 C 809 | 65 N 810 | 66 I 811 | 67 L 812 | 68 H 813 | 69 A 814 | 70 D 815 | 71 I 816 | 72 K 817 | 73 P 818 | 74 D 819 | 75 N 820 | 76 I 821 | 77 L 822 | 78 V 823 | 79 L 832 | 80 C 833 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 834 | 82 F 835 | 83 G 836 | 84 S 837 | 85 A 838 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
