PDB-code
| Kinase structure | |
| Kinase: | CSF1R (FMS) |
| Family: | PDGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1806 |
| PDB: | 6T2W |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2020-01-01 |
| PubMed: | 31851518 |
| Chain: | A |
| Orthosteric ligand: | M9T |
 | |
| Structural information | |
| DFG conformation: | out |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 60.1° (18.1Å) |
| G-rich loop rotation: | 49.2° |
| Quality Score: | 8 |
| Resolution: | 1.7 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | Cluster I1 I5 | Ligand No No | Protein Yes No | |
| Pocket alignment | |
| Uniprot sequence: | KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDVAARNVLLIGDFGLA |
| Sequence structure: | KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDVAARNVLLIGDFGLA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 586 | 2 T 587 | 3 L 588 | 4 G 589 | 5 A 590 | 6 G 591 | 7 A 592 | 8 F 593 | 9 G 594 | 10 K 595 | 11 V 596 | 12 V 597 | 13 E 598 | 14 V 613 | 15 A 614 | 16 V 615 | 17 K 616 | 18 M 617 | 19 L 618 | 20 A 629 |
| αC | b.l | IV | |||||||||||||||||
| 21 L 630 | 22 M 631 | 23 S 632 | 24 E 633 | 25 L 634 | 26 K 635 | 27 I 636 | 28 M 637 | 29 S 638 | 30 H 639 | 31 L 640 | 32 G 641 | 33 E 644 | 34 N 645 | 35 I 646 | 36 V 647 | 37 N 648 | 38 L 649 | 39 L 650 | 40 G 651 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 652 | 42 L 660 | 43 V 661 | 44 I 662 | 45 T 663 | 46 E 664 | 47 Y 665 | 48 C 666 | 49 C 667 | 50 Y 668 | 51 G 669 | 52 D 670 | 53 L 671 | 54 L 672 | 55 N 673 | 56 F 674 | 57 L 675 | 58 R 676 | 59 R 677 | 60 F 768 |
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 769 | 62 A 770 | 63 S 771 | 64 K 772 | 65 N 773 | 66 C 774 | 67 I 775 | 68 H 776 | 69 R 777 | 70 D 778 | 71 V 779 | 72 A 780 | 73 A 781 | 74 R 782 | 75 N 783 | 76 V 784 | 77 L 785 | 78 L 786 | 79 I 794 | 80 G 795 |
| DFG | a.l | ||||||||||||||||||
| 81 D 796 | 82 F 797 | 83 G 798 | 84 L 799 | 85 A 800 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
