Spleen tyrosine kinase
Kinase structure
Kinase:SYK
Family:Syk
Group:TK
Species:HUMAN
IUPHAR/BPS ID:2230
PDB:1XBA
sc-PDB:
KIDFamMap:Search
Release date:2004-11-02
PubMed: 15507431
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):57.2° (17.6Å)
G-rich loop rotation:74.1°
Quality Score:8.3
Resolution:2 Å
Missing Residues:0
Missing Atoms:17
Ligand binding mode
Waters
Cluster
I4
I6
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS
Sequence structure:KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS