Search results (137 entries covering 78 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	SYK	Syk	TK	4yjo	A	B	5-chloro-n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	4rx8	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	Show
	SYK	Syk	TK	4f4p	A	B	n-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine	Human	Show
	SYK	Syk	TK	4dfn	A	A	3-amino-6-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]-n-[(1r,2r,3s,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide	Human	Show
	SYK	Syk	TK	4fl3	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	SYK	Syk	TK	5lmb	A	A	7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine	Human	Show
	SYK	Syk	TK	4i0r	A	B	n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	5cy3	A	B	(5r)-5-[(1r)-1-{[6-(1-methyl-1h-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one	Human	Show
	SYK	Syk	TK	4yjv	A	B	3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol	Human	Show
	SYK	Syk	TK	4yjq	A	A	3-[1h-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol	Human	Show
	SYK	Syk	TK	6zcs	A	A	(3~{r},4~{r})-~{n}4-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine	Human	Show
	SYK	Syk	TK	4yjs	A		3-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1h-indazol-4-yl)amino]propan-1-ol	Human	Show
	SYK	Syk	TK	4f4p	A	A	n-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine	Human	Show
	SYK	Syk	TK	4yjt	A	C	n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	4puz	B		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	Show
	SYK	Syk	TK	5t68	A		n~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	5tr6	A	B	6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one	Human	Show
	SYK	Syk	TK	5cxz	A	B	n-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine	Human	Show
	SYK	Syk	TK	4yjv	A	C	3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol	Human	Show
	SYK	Syk	TK	6hm7	A	B	7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{h}-3-benzazepine	Human	Show
	SYK	Syk	TK	6ssb	A		~{n}-[4-[5-[(dimethylamino)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-yl]-3-methyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)imidazo[1,5-a]pyridin-7-amine	Human	Show
	SYK	Syk	TK	8x5k	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	5y5t	A		2-[[(1s,2s)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6h-pyrido[4,3-d]pyrimidin-5-one	Human	Show
	SYK	Syk	TK	4wnm	A		n~3~-(tetrahydro-2h-pyran-4-yl)-n~6~-[5-(tetrahydro-2h-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1h-indazole-3,6-diamine	Human	Show
	SYK	Syk	TK	4px6	A	B	7-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3h)-one	Human	Show
	SYK	Syk	TK	6vov	A		6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine	Human	Show
	SYK	Syk	TK	4fl3	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	SYK	Syk	TK	6zcr	A	A	6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine	Human	Show
	SYK	Syk	TK	5tt7	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	Show
	SYK	Syk	TK	3fqs	A	B	6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one	Human	Show
	SYK	Syk	TK	4yjt	A	B	n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	6zcr	A	B	6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine	Human	Show
	SYK	Syk	TK	4rss	A	B	1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	3vf8	A		3-[5-(5-ethoxy-6-fluoro-1h-benzimidazol-2-yl)-1h-pyrazol-4-yl]-1,1-diethylurea	Human	Show
	SYK	Syk	TK	4i0s	A	A	2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	6zcp	A		7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{n},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide	Human	Show
	SYK	Syk	TK	4rx9	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	3fqh	A		n-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indole-5-carboxamide	Human	Show
	SYK	Syk	TK	4fyo	A	B	4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid	Human	Show
	SYK	Syk	TK	6hm7	A	A	7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{h}-3-benzazepine	Human	Show
	SYK	Syk	TK	4xg7	A	A	1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	4rx7	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	Show
	SYK	Syk	TK	6zcq	A		7-[[4-[4-[[(3~{r},4~{r})-3-azanyloxan-4-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{n},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide	Human	Show
	SYK	Syk	TK	4fz6	A	A	n-{6-[(2s)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine	Human	Show
	SYK	Syk	TK	4rx9	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	3fqs	A	A	6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one	Human	Show
	SYK	Syk	TK	5tr6	A	A	6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one	Human	Show
	SYK	Syk	TK	5t68	B		n~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	5cy3	A	A	(5r)-5-[(1r)-1-{[6-(1-methyl-1h-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one	Human	Show
	SYK	Syk	TK	3srv	A	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	6hm6	A	B	2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine	Human	Show
	SYK	Syk	TK	4xg3	A		4-{[5-fluoro-4-(3-{[(3r)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1h-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate	Human	Show
	SYK	Syk	TK	4yjt	A	A	n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	4puz	A		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	Show
	SYK	Syk	TK	5y5u	B		4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8h-pyrido[4,3-d]pyrimidin-5-one	Human	Show
	SYK	Syk	TK	4yjv	A	A	3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol	Human	Show
	SYK	Syk	TK	5y5u	A		4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8h-pyrido[4,3-d]pyrimidin-5-one	Human	Show
	SYK	Syk	TK	6zcy	A	A	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	Show
	SYK	Syk	TK	1xbb	A	B	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	SYK	Syk	TK	4fz7	A	B	6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide	Human	Show
	SYK	Syk	TK	4yju	A	A	n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-n~4~-(1h-indazol-4-yl)-n~4~-methylpyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	5lmb	B	A	7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine	Human	Show
	SYK	Syk	TK	4fyn	A	B	3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol	Human	Show
	SYK	Syk	TK	3fqe	A		2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	4xg4	A		(3r)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1h-pyrrol-3-yl]methyl}pyrrolidin-3-ol	Human	Show
	SYK	Syk	TK	6zcu	A	B	6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine	Human	Show
	SYK	Syk	TK	5ghv	A		1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1h-pyrrol-3-yl}methyl)azetidin-3-ol	Human	Show
	SYK	Syk	TK	6zc0	A		~{n},~{n}-dimethyl-1-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]methanamine	Human	Show
	SYK	Syk	TK	5tt7	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	Show
	SYK	Syk	TK	6hm6	A	A	2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine	Human	Show
	SYK	Syk	TK	3tuc	A		1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	Show
	SYK	Syk	TK	1xbc	A	B	staurosporine	Human	Show
	SYK	Syk	TK	4i0s	A	B	2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	4yjp	A		2-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1h-indazol-4-yl)amino]ethanol	Human	Show
	SYK	Syk	TK	4xg8	C		1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	5lmb	B	B	7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine	Human	Show
	SYK	Syk	TK	6zcx	A	B	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	Show
	SYK	Syk	TK	3fqh	B		n-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indole-5-carboxamide	Human	Show
	SYK	Syk	TK	5tiu	A	B	5-{[(2s)-2-aminopropyl]amino}-3-(1h-indol-2-yl)pyrazine-2-carboxamide	Human	Show
	SYK	Syk	TK	5c26	A		3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide	Human	Show
	SYK	Syk	TK	4xg2	A		-	Human	Show
	SYK	Syk	TK	4fyo	A	A	4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid	Human	Show
	SYK	Syk	TK	6vov	B		6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine	Human	Show
	SYK	Syk	TK	6zcy	A	B	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	Show
	SYK	Syk	TK	4yju	A	B	n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-n~4~-(1h-indazol-4-yl)-n~4~-methylpyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	3tud	A		n-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide	Human	Show
	SYK	Syk	TK	4i0t	A	A	n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	4rx7	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	Show
	SYK	Syk	TK	4i0r	A	A	n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	4fz7	A	A	6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide	Human	Show
	SYK	Syk	TK	4fl1	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	SYK	Syk	TK	4yjr	A	B	3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol	Human	Show
	SYK	Syk	TK	5cxz	A	A	n-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine	Human	Show
	SYK	Syk	TK	4fl1	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	SYK	Syk	TK	4xg9	B		1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	5cxh	A		(4r)-4-[(1r)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one	Human	Show
	SYK	Syk	TK	4dfn	A	B	3-amino-6-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]-n-[(1r,2r,3s,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide	Human	Show
	SYK	Syk	TK	4px6	A	A	7-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3h)-one	Human	Show
	SYK	Syk	TK	6zcu	A	A	6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine	Human	Show
	SYK	Syk	TK	4xg9	A		1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	5c27	A		3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-n-[4-(methylcarbamoyl)phenyl]benzamide	Human	Show
	SYK	Syk	TK	4dfl	A		3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-n-(piperidin-4-ylmethyl)pyrazine-2-carboxamide	Human	Show
	SYK	Syk	TK	4gfg	A		6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide	Human	Show
	SYK	Syk	TK	6zcs	A	B	(3~{r},4~{r})-~{n}4-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine	Human	Show
	SYK	Syk	TK	5lma	A	A	~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine	Human	Show
	SYK	Syk	TK	3vf9	A		3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol	Human	Show
	SYK	Syk	TK	4xg3	B		4-{[5-fluoro-4-(3-{[(3r)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1h-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate	Human	Show
	SYK	Syk	TK	4xg6	A		1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	4xg8	A		1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	4xg7	A	B	1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	3emg	A		2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-n-[(1s)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide	Human	Show
	SYK	Syk	TK	5tiu	A	A	5-{[(2s)-2-aminopropyl]amino}-3-(1h-indol-2-yl)pyrazine-2-carboxamide	Human	Show
	SYK	Syk	TK	5lma	A	C	~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine	Human	Show
	SYK	Syk	TK	4yjr	A	C	3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol	Human	Show
	SYK	Syk	TK	4yjr	A	A	3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol	Human	Show
	SYK	Syk	TK	1xba	A		-	Human	Show
	SYK	Syk	TK	6zcx	A	A	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	Show
	SYK	Syk	TK	3tub	A		1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]urea	Human	Show
	SYK	Syk	TK	1xbc	A	A	staurosporine	Human	Show
	SYK	Syk	TK	4rss	A	A	1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	Show
	SYK	Syk	TK	1xbb	A	A	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	SYK	Syk	TK	3srv	A	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	4yjq	A	B	3-[1h-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol	Human	Show
	SYK	Syk	TK	4pv0	A		4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid	Human	Show
	SYK	Syk	TK	4fyn	A	A	3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol	Human	Show
	SYK	Syk	TK	3srv	B	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	5ghv	B		1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1h-pyrrol-3-yl}methyl)azetidin-3-ol	Human	Show
	SYK	Syk	TK	5lmb	A	B	7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine	Human	Show
	SYK	Syk	TK	5lma	A	B	~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine	Human	Show
	SYK	Syk	TK	4fl2	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	SYK	Syk	TK	3srv	B	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	4rx8	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	Show
	SYK	Syk	TK	8bi2	A		10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one	Human	Show
	SYK	Syk	TK	8x5k	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	Show
	SYK	Syk	TK	4i0t	A	B	n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide	Human	Show
	SYK	Syk	TK	4yjo	A	A	5-chloro-n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine	Human	Show
	SYK	Syk	TK	4fz6	A	B	n-{6-[(2s)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam