PDB-code
| Kinase structure | |
| Kinase: | MAPK6 (Erk3) |
| Family: | MAPK |
| Group: | CMGC |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2092 |
| PDB: | 6YKY |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2020-09-22 |
| PubMed: | 32927028 |
| Chain: | D |
| (Alternate) Model: | A |
| Orthosteric ligand: | OWQ |
 | |
| More entries for 6YKY | |||||
| 6YKY | Alternative model: | A | Chain: | A | |
| 6YKY | Alternative model: | A | Chain: | B | |
| 6YKY | Alternative model: | A | Chain: | C | |
| 6YKY | Alternative model: | B | Chain: | A | |
| 6YKY | Alternative model: | B | Chain: | B | |
| 6YKY | Alternative model: | B | Chain: | C | |
| 6YKY | Alternative model: | B | Chain: | D | |
| Structural information | |
| DFG conformation: | out-like |
| αC-helix conformation: | out |
| G-rich loop angle (distance): | 65.7° (20Å) |
| G-rich loop rotation: | 80.7° |
| Quality Score: | 8 |
| Resolution: | 2.52 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front | ||||
| Pocket alignment | |
| Uniprot sequence: | KPLGCGGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME-TDLANVLEQYIHSANVLHRDLKPANLFIIGDFGLA |
| Sequence structure: | KPLGCGGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFGLA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 24 | 2 P 25 | 3 L 26 | 4 G 27 | 5 C 28 | 6 G 29 | 7 G 30 | 8 N 31 | 9 G 32 | 10 L 33 | 11 V 34 | 12 F 35 | 13 S 36 | 14 V 46 | 15 A 47 | 16 I 48 | 17 K 49 | 18 K 50 | 19 I 51 | 20 H 61 |
| • | • | • | • | • | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 A 62 | 22 L 63 | 23 R 64 | 24 E 65 | 25 I 66 | 26 K 67 | 27 I 68 | 28 I 69 | 29 R 70 | 30 R 71 | 31 L 72 | 32 D 73 | 33 D 75 | 34 N 76 | 35 I 77 | 36 V 78 | 37 K 79 | 38 V 80 | 39 F 81 | 40 E 82 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 83 | 42 Y 105 | 43 I 106 | 44 V 107 | 45 Q 108 | 46 E 109 | 47 Y 110 | 48 M 111 | 49 E 112 | 50 _ _ | 51 T 113 | 52 D 114 | 53 L 115 | 54 A 116 | 55 N 117 | 56 V 118 | 57 L 119 | 58 E 120 | 59 Q 121 | 60 Y 142 |
| • | • | ••• | • | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 I 143 | 62 H 144 | 63 S 145 | 64 A 146 | 65 N 147 | 66 V 148 | 67 L 149 | 68 H 150 | 69 R 151 | 70 D 152 | 71 L 153 | 72 K 154 | 73 P 155 | 74 A 156 | 75 N 157 | 76 L 158 | 77 F 159 | 78 I 160 | 79 I 169 | 80 G 170 |
| ••• | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 171 | 82 F 172 | 83 G 173 | 84 L 174 | 85 A 175 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
