Mitogen-activated protein kinase-activated protein kinase 2
Kinase structure
Kinase:MAPKAPK2
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2094
PDB:1KWP
sc-PDB:
KIDFamMap:Search
Release date:2002-09-18
PubMed: 12171911
Chain:A
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The orthosteric binding pocket


More entries for 1KWP
1KWPChain: B


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):68.1° (19.4Å)
G-rich loop rotation:67.2°
Quality Score:8
Resolution:2.8 Å
Missing Residues:0
Missing Atoms:26
Ligand binding mode
Waters
Cluster
I6
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA
Sequence structure:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA