Interleukin 1 receptor associated kinase 4
Kinase structure
Kinase:IRAK4
Family:IRAK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2045
PDB:7C2W
sc-PDB:
KIDFamMap:Search
Release date:2020-11-25
PubMed: 33335659
Chain:D
(Alternate) Model:A
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The orthosteric binding pocket


More entries for 7C2W
7C2WAlternative model: AChain: A
7C2WAlternative model: AChain: B
7C2WAlternative model: AChain: C


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):48.4° (15.1Å)
G-rich loop rotation:57.9°
Quality Score:8
Resolution:3.2 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Sequence structure:NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA