Search results (306 entries covering 79 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	IRAK4	IRAK	TKL	6o8u	D	A	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4u9a	A		staurosporine	Human	Show
	IRAK4	IRAK	TKL	6ega	B	B	3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	6vql	C		6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8tx0	A		~{n}-(1-cyclopropyl-2-oxidanylidene-pyridin-3-yl)-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-7-propan-2-yloxy-imidazo[1,2-a]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8v1o	A		n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8ucb	A		6-(difluoromethyl)-n-[(4r)-7-ethoxy-2-{[(3r)-oxolan-3-yl]methyl}imidazo[1,2-a]pyridin-6-yl]pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4u9a	B		staurosporine	Human	Show
	IRAK4	IRAK	TKL	8tvn	A	B	n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8v2f	A	A	n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6mom	B	B	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5w85	A		6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uiq	A	A	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	5uit	A		1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7qg5	A	A	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one	Human	Show
	IRAK4	IRAK	TKL	7qg1	A		methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	6vql	B		6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5t1t	C		~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine	Human	Show
	IRAK4	IRAK	TKL	6eg9	A	B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	6ti8	C	A	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o95	A	A	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5kx8	D		~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6thz	A		7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	4ztm	C		5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	6o8u	A	B	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nru	A	A	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	2oic	A		staurosporine	Human	Show
	IRAK4	IRAK	TKL	5k75	C	B	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	4ztn	A	A	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	6f3g	B		~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	4ztn	C	B	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	8atn	A	A	~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yp8	C		n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6ege	D	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atb	A	A	~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k75	D	B	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6o8u	B	A	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8br5	A	B	~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8br6	A	B	~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8br6	A	A	~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8br7	A		3-nitro-~{n}-[2-[2-oxidanylidene-2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]indazol-5-yl]benzamide	Human	Show
	IRAK4	IRAK	TKL	4ztn	A	B	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	5uiq	C	B	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	5uiq	B	A	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	5kx8	A		~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6n8g	B	A	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o8u	D	B	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	C	A	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oic	D		staurosporine	Human	Show
	IRAK4	IRAK	TKL	6o9d	D	B	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	A	A	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k7g	D		(3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	6mom	D	B	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5k7g	A		(3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	6o94	B	A	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o8u	C	B	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	B	B	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6vql	D		6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6uya	A	A	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o8u	B	B	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uit	B		1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8br5	A	A	~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nru	B	B	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	6lxy	D		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7c2w	A	A	-	Human	Show
	IRAK4	IRAK	TKL	4ztl	A	B	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	4ztn	B	A	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	5uis	D	A	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	C	A	staurosporine	Human	Show
	IRAK4	IRAK	TKL	8dks	A	B	(1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8dks	A	A	(1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6mom	D	A	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5uis	B	A	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atl	A	B	~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8wtf	A	A	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atl	B	A	~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8wtf	A	B	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atn	A	B	~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atl	A	A	~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k7g	B		(3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	5k75	B	A	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	8atl	B	B	~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	A	A	staurosporine	Human	Show
	IRAK4	IRAK	TKL	2nru	A	B	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	6rfi	B	B	methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	4y73	A	B	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6f3g	A		~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	4xs2	D		(1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	4xs2	B		(1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	5uis	C	A	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4u97	A		staurosporine	Human	Show
	IRAK4	IRAK	TKL	5uis	C	B	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4rmz	B	B	3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide	Human	Show
	IRAK4	IRAK	TKL	6eg9	B	A	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	5k75	D	A	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	5kx8	C		~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5w84	B		4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	D	B	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	5k75	C	A	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6ega	B	A	3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	C	B	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	B	B	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	6o95	C	B	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	D	A	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k75	B	B	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6uya	D	B	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uis	A	B	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	D	A	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	4rmz	B	A	3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide	Human	Show
	IRAK4	IRAK	TKL	6egd	D	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6n8g	D	A	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oid	D		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IRAK4	IRAK	TKL	5t1s	D		5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol	Human	Show
	IRAK4	IRAK	TKL	5uir	A	B	5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8atb	A	B	~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	C	B	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4u97	B		staurosporine	Human	Show
	IRAK4	IRAK	TKL	6f3d	A		4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oic	B		staurosporine	Human	Show
	IRAK4	IRAK	TKL	5t1s	A		5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol	Human	Show
	IRAK4	IRAK	TKL	4yp8	D		n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uiu	A	A	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6ti8	D	B	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	A	B	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6f3d	B		4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k76	B	B	~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IRAK4	IRAK	TKL	6o9d	C	A	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yp8	A		n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5kx8	B		~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	D	B	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	D	B	staurosporine	Human	Show
	IRAK4	IRAK	TKL	2nru	D	A	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	6ti8	A	A	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6n8g	A	A	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uiq	B	B	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	6ti8	C	B	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	C	B	staurosporine	Human	Show
	IRAK4	IRAK	TKL	6ti8	B	A	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6uya	D	A	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6thw	A		7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5uiu	B	B	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7c2v	A	A	2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	C	B	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uiu	B	A	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o95	D	B	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6f3i	B		(3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide	Human	Show
	IRAK4	IRAK	TKL	5uiu	A	B	1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7qg3	A		6-[(2~{s})-2-fluoranylpropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one	Human	Show
	IRAK4	IRAK	TKL	5t1t	D		~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine	Human	Show
	IRAK4	IRAK	TKL	4xs2	C		(1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	5t1t	A		~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine	Human	Show
	IRAK4	IRAK	TKL	5uis	B	B	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oid	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IRAK4	IRAK	TKL	6n8g	D	B	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6mom	A	A	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	6f3e	B		2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide	Human	Show
	IRAK4	IRAK	TKL	6o94	A	B	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yp8	B		n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6ege	A	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4rmz	A	B	3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide	Human	Show
	IRAK4	IRAK	TKL	7c2w	B	A	-	Human	Show
	IRAK4	IRAK	TKL	6thz	B		7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	6ti8	B	B	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oid	B		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IRAK4	IRAK	TKL	6egf	B		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IRAK4	IRAK	TKL	2oib	A	A	-	Human	Show
	IRAK4	IRAK	TKL	6o95	D	A	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6uya	C	B	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	C	A	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	6egd	A	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nru	C	A	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	2nry	A	B	staurosporine	Human	Show
	IRAK4	IRAK	TKL	6n8g	B	B	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6rfi	B	A	methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	2oib	C	A	-	Human	Show
	IRAK4	IRAK	TKL	6lxy	B		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztm	B		5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	7c2w	D	A	-	Human	Show
	IRAK4	IRAK	TKL	2oic	C		staurosporine	Human	Show
	IRAK4	IRAK	TKL	6n8g	C	B	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	B	B	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uir	B	B	5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o95	B	A	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oib	B	B	-	Human	Show
	IRAK4	IRAK	TKL	4xs2	A		(1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	5t1s	C		5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol	Human	Show
	IRAK4	IRAK	TKL	2oid	C		phosphoaminophosphonic acid-adenylate ester	Human	Show
	IRAK4	IRAK	TKL	5k72	A		~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6ege	A	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	C	A	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k7i	A		(3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	5k76	B	A	~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IRAK4	IRAK	TKL	5k72	C		~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6eg9	B	B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	6tia	A		4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5k7g	C		(3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	2o8y	A		-	Human	Show
	IRAK4	IRAK	TKL	8v2f	A	B	n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8v2l	A	A	n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o95	C	A	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7qg2	A	A	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one	Human	Show
	IRAK4	IRAK	TKL	6tia	B		4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5kx7	B		~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	B	A	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztn	D	A	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	2oib	D	B	-	Human	Show
	IRAK4	IRAK	TKL	6ega	A	B	3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	2oib	B	A	-	Human	Show
	IRAK4	IRAK	TKL	4ztl	B	A	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	8ucc	A		(4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	C	A	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6mom	C	B	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	8v2l	A	B	n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6thx	A		2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile	Human	Show
	IRAK4	IRAK	TKL	8tvm	A	B	n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6egd	D	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o9d	B	A	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o95	A	B	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k75	A	A	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	5k75	A	B	~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6o9d	A	A	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o9d	A	B	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o9d	C	B	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nru	B	A	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	8tvm	A	A	n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	8tvn	A	A	n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	A	A	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k72	B		~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	5t1t	B		~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine	Human	Show
	IRAK4	IRAK	TKL	6mom	C	A	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	6rfi	A	A	methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	2nru	D	B	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	6o8u	A	A	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uiq	C	A	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	2oib	A	B	-	Human	Show
	IRAK4	IRAK	TKL	4ztn	B	B	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	6o95	B	B	n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2oib	C	B	-	Human	Show
	IRAK4	IRAK	TKL	6mom	B	A	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	2oib	D	A	-	Human	Show
	IRAK4	IRAK	TKL	5uiq	A	B	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	4ztn	D	B	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	7qg5	A	B	4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one	Human	Show
	IRAK4	IRAK	TKL	4rmz	A	A	3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide	Human	Show
	IRAK4	IRAK	TKL	6thx	B		2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile	Human	Show
	IRAK4	IRAK	TKL	5uiq	D	A	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	5uir	B	A	5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uis	A	A	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k72	D		~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine	Human	Show
	IRAK4	IRAK	TKL	6eg9	A	A	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	7c2v	C	A	2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6vql	A		6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6uya	A	B	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6lxy	E		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o9d	B	B	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5w85	B		6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6uya	C	A	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	D	A	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6rfj	B		methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	5uiq	D	B	2-[(propan-2-yl)oxy]benzamide	Human	Show
	IRAK4	IRAK	TKL	2o8y	B		-	Human	Show
	IRAK4	IRAK	TKL	6f3i	A		(3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide	Human	Show
	IRAK4	IRAK	TKL	6o9d	D	A	n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	B	B	staurosporine	Human	Show
	IRAK4	IRAK	TKL	7qg2	A	B	6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one	Human	Show
	IRAK4	IRAK	TKL	6n8g	C	A	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6mom	A	B	6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine	Human	Show
	IRAK4	IRAK	TKL	5w84	A		4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4y73	B	A	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	A	A	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	6uya	B	B	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o94	A	A	n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5kx7	A		-	Human	Show
	IRAK4	IRAK	TKL	4y73	D	B	5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5t1s	B		5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol	Human	Show
	IRAK4	IRAK	TKL	4ztm	A		5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	4yo6	B	B	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k76	A	A	~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IRAK4	IRAK	TKL	6uya	B	A	n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5uir	A	A	5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k7i	B		(3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one	Human	Show
	IRAK4	IRAK	TKL	5uis	D	B	4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide	Human	Show
	IRAK4	IRAK	TKL	5k76	A	B	~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	IRAK4	IRAK	TKL	6ege	D	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6o8u	C	A	n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6n8g	A	B	n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztm	D		5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	6rfi	A	B	methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	6ti8	A	B	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4ztl	C	B	(1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol	Human	Show
	IRAK4	IRAK	TKL	8ucc	B		(4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6egd	A	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	Show
	IRAK4	IRAK	TKL	2nry	B	A	staurosporine	Human	Show
	IRAK4	IRAK	TKL	2nry	D	A	staurosporine	Human	Show
	IRAK4	IRAK	TKL	7c2v	A	B	2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6rfj	A		methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate	Human	Show
	IRAK4	IRAK	TKL	2nru	C	B	1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate	Human	Show
	IRAK4	IRAK	TKL	4yo6	D	B	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	4yo6	D	A	n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	IRAK4	IRAK	TKL	7c2w	C	A	-	Human	Show
	IRAK4	IRAK	TKL	6ega	A	A	3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	IRAK4	IRAK	TKL	6thw	B		7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine	Human	Show
	IRAK4	IRAK	TKL	4ztn	C	A	5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one	Human	Show
	IRAK4	IRAK	TKL	6ti8	D	A	~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide	Human	Show
	IRAK4	IRAK	TKL	6f3e	A		2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide	Human	Show
	IRAK4	IRAK	TKL	7c2v	C	B	2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam