PDB-code
| Kinase structure | |
| Kinase: | STK24 (MST3) |
| Family: | STE20 |
| Group: | STE |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2217 |
| PDB: | 7B35 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2020-12-16 |
| PubMed: | 34086472 |
| Chain: | B |
| Orthosteric ligand: | SQB |
 | |
| More entries for 7B35 | |||
| 7B35 | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 61.3° (17.6Å) |
| G-rich loop rotation: | 71.7° |
| Quality Score: | 8.5 |
| Resolution: | 2.40005 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 15 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front gate back | BP-I-A BP-I-B | Cluster I1 I10 | Ligand No Yes | Protein No Yes |
| Pocket alignment | |
| Uniprot sequence: | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
| Sequence structure: | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
| Ligand affinity | |
| Ligand not found in ChEMBL. | |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 40 | 2 K 41 | 3 I 42 | 4 G 43 | 5 K 44 | 6 G 45 | 7 S 46 | 8 F 47 | 9 G 48 | 10 E 49 | 11 V 50 | 12 F 51 | 13 K 52 | 14 V 62 | 15 A 63 | 16 I 64 | 17 K 65 | 18 I 66 | 19 I 67 | 20 D 78 |
| • | • | • | • | • | •• | • | |||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 79 | 22 Q 80 | 23 Q 81 | 24 E 82 | 25 I 83 | 26 T 84 | 27 V 85 | 28 L 86 | 29 S 87 | 30 Q 88 | 31 C 89 | 32 D 90 | 33 P 92 | 34 Y 93 | 35 V 94 | 36 T 95 | 37 K 96 | 38 Y 97 | 39 Y 98 | 40 G 99 |
| • | • | • | • | • | |||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 S 100 | 42 W 108 | 43 I 109 | 44 I 110 | 45 M 111 | 46 E 112 | 47 Y 113 | 48 L 114 | 49 G 115 | 50 G 116 | 51 G 117 | 52 S 118 | 53 A 119 | 54 L 120 | 55 D 121 | 56 L 122 | 57 L 123 | 58 E 124 | 59 P 125 | 60 Y 146 |
| • | • | • | • | ••• | • | ||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 147 | 62 H 148 | 63 S 149 | 64 E 150 | 65 K 151 | 66 K 152 | 67 I 153 | 68 H 154 | 69 R 155 | 70 D 156 | 71 I 157 | 72 K 158 | 73 A 159 | 74 A 160 | 75 N 161 | 76 V 162 | 77 L 163 | 78 L 164 | 79 L 172 | 80 A 173 |
| •• | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 174 | 82 F 175 | 83 G 176 | 84 V 177 | 85 A 178 | |||||||||||||||
| ••• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
