Version: 3.2
Updated: 29-Oct-2025
Calcium/calmodulin-dependent protein kinase II alpha
Kinase structure
Kinase:CAMK2A (CaMK2a)
Family:CAMK2
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:1555
PDB:7KL2
sc-PDB:
KIDFamMap:Search
Release date:2020-12-23
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):62.7° (18.8Å)
G-rich loop rotation:48.6°
Quality Score:8.7
Resolution:2.56 Å
Missing Residues:0
Missing Atoms:13
Ligand binding mode
Waters
Cluster
I2
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRDLKPENLLLLADFGLA
Sequence structure:EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRNLKPENLLLLADFGLA