KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	JAK2
Family:	JakA
Group:	TK
Species:	HUMAN
PDB:	6VGL
sc-PDB:
KIDFamMap:	Search
Release date:	2021-01-13
PubMed:	33570945
Chain:	A
Orthosteric ligand:	RXT

More entries for 6VGL
6VGL	Chain:	B
6VGL	Chain:	C
6VGL	Chain:	D

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	48.6° (15.2Å)
G-rich loop rotation:	51.8°
Quality Score:	8
Resolution:	1.9 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front	FP-I FP-II	Cluster I1 I4 I7 I11	Ligand No No Yes No	Protein Yes Yes Yes Yes

Pocket alignment
Uniprot sequence:	QQLGKGNFGSVEMVAVKKLDFEREIEILKSLQDNIVKYKGVKLIMEYLPYGSLRDYLQKYLGTKRYIHRDLATRNILVIGDFGLT
Sequence structure:	QQLGKGNFGSVEMVAVKKLDFEREIEILKSLQDNIVKYKGVKLIMEYLPYGSLRDYLQKYLGTKRYIHRDLATRNILVIGDFGLT

Ligand affinity
ChEMBL ID:	CHEMBL1789941
Bioaffinities:	274 records for 117 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Adaptor-associated kinase	6.9	6.9	6.9	pKd	1
Homo sapiens	ALK tyrosine kinase receptor	5.8	5.8	5.8	pKd	1
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	6.4	6.4	6.4	pKd	1
Homo sapiens	BMP-2-inducible protein kinase	6.7	6.7	6.7	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-1B	5.8	5.8	5.8	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	6	6	6	pKd	1
Homo sapiens	CaM kinase I alpha	6.3	6.3	6.3	pKd	1
Homo sapiens	CaM kinase I delta	6.9	6.9	6.9	pKd	1
Homo sapiens	CaM kinase I gamma	5.7	5.7	5.7	pKd	1
Homo sapiens	CaM kinase II alpha	7.3	7.3	7.3	pKd	1
Homo sapiens	CaM kinase II beta	6.5	6.5	6.5	pKd	1
Homo sapiens	CaM kinase II delta	7.1	7.1	7.1	pKd	1
Homo sapiens	CaM kinase II gamma	7	7	7	pKd	1
Homo sapiens	Casein kinase I alpha	5.8	5.8	5.8	pKd	1
Homo sapiens	Casein kinase II alpha	5.4	5.4	5.4	pKd	1
Homo sapiens	Casein kinase II alpha (prime)	5.5	5.5	5.5	pKd	1
Homo sapiens	cGMP-dependent protein kinase 2	6.2	6.2	6.2	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	5.3	5.3	5.3	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	5.5	5.5	5.5	pKd	1
Homo sapiens	Death-associated protein kinase 1	7.1	7.1	7.1	pKd	1
Homo sapiens	Death-associated protein kinase 2	7	7	7	pKd	1
Homo sapiens	Death-associated protein kinase 3	7.1	7.1	7.1	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.7	5.7	5.7	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.4	5.4	5.4	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	6.3	6.3	6.3	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	6.3	6.3	6.3	pKd	2
Homo sapiens	Dual specificity protein kinase CLK4	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity protein kinase TTK	6.3	6.3	6.3	pKd	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	6	6	6	pKd	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	5.4	5.4	5.4	pKd	1
Homo sapiens	Ephrin type-A receptor 3	5.2	5.2	5.2	pKd	1
Homo sapiens	G protein-coupled receptor kinase 4	5.2	5.2	5.2	pKd	1
Homo sapiens	G protein-coupled receptor kinase 7	6.3	6.3	6.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 1	5.9	5.9	5.9	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6	6	6	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	5.9	5.9	5.9	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	5.6	5.6	5.6	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	5.9	5.9	5.9	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	6.5	6.5	6.5	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.5	6.5	7.1	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	6.4	6.4	6.4	pKd	1
Homo sapiens	MAP kinase signal-integrating kinase 2	6.7	6.7	6.7	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.2	6.2	6.2	pKd	1
Homo sapiens	Maternal embryonic leucine zipper kinase	5.7	5.7	5.7	pKd	1
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	6.3	6.3	6.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 15	6	6	6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.4	7.4	7.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.8	6.8	6.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	6.1	6.1	6.1	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	6.4	6.4	6.4	pKd	1
Homo sapiens	Myotonin-protein kinase	5.5	5.5	5.5	pKd	1
Homo sapiens	Nerve growth factor receptor Trk-A	5.8	5.8	5.8	pKd	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.4	6.4	6.4	pKd	1
Homo sapiens	NT-3 growth factor receptor	6.5	6.5	6.5	pKd	1
Homo sapiens	NUAK family SNF1-like kinase 2	6.5	6.5	6.5	pKd	1
Homo sapiens	Phosphorylase kinase gamma subunit 1	5.2	5.2	5.2	pKd	1
Homo sapiens	Phosphorylase kinase gamma subunit 2	6	6	6	pKd	1
Homo sapiens	Protein kinase C epsilon	6.3	6.3	6.3	pKd	1
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	5.2	5.2	5.2	pKd	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	5.7	5.7	5.7	pKd	1
Homo sapiens	Rho-associated protein kinase 1	7.2	7.2	7.2	pKd	1
Homo sapiens	Rho-associated protein kinase 2	7.3	7.3	7.3	pKd	1
Homo sapiens	Rhodopsin kinase	6.1	6.1	6.1	pKd	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.9	6.9	6.9	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 2	6.8	6.8	6.8	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 4	6.5	6.5	6.5	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6.9	6.9	6.9	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.9	5.9	6.8	pKd	4
Homo sapiens	Serine/threonine-protein kinase 16	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17A	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17B	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase 25	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase B-raf	5.4	5.4	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase DCLK1	7.2	7.2	7.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase DCLK2	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase GAK	7	7	7	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek3	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK7	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase OSR1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK6	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK7	5.9	5.9	5.9	pKd	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK1	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK3	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO2	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase SBK1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK3	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase SRPK3	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO2	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK1	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK2	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	5.6	5.6	5.6	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	6.6	6.6	6.6	pKd	1
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	5.7	5.7	5.7	pKd	1
Homo sapiens	Stem cell growth factor receptor	5.2	5.2	5.2	pKd	3
Homo sapiens	Tyrosine kinase non-receptor protein 2	5.6	5.6	5.6	pKd	1
Homo sapiens	Tyrosine-protein kinase ABL	5.5	5	6	pKd	8
Homo sapiens	Tyrosine-protein kinase JAK1	7.6	7.6	7.6	pEC50	4
Homo sapiens	Tyrosine-protein kinase JAK1	8.5	6	9.4	pIC50	28
Homo sapiens	Tyrosine-protein kinase JAK1	8.5	8.5	8.5	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK1	9.7	9.7	10.1	pKi	6
Homo sapiens	Tyrosine-protein kinase JAK2	7.9	7.9	7.9	pEC50	4
Homo sapiens	Tyrosine-protein kinase JAK2	8.2	5.3	10.3	pIC50	38
Homo sapiens	Tyrosine-protein kinase JAK2	10.4	10.4	10.4	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK2	10	9.6	10	pKi	6
Homo sapiens	Tyrosine-protein kinase JAK3	6.4	5.7	8.6	pIC50	16
Homo sapiens	Tyrosine-protein kinase JAK3	8.7	8.7	8.7	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK3	8.5	8.5	8.5	pKi	6
Homo sapiens	Tyrosine-protein kinase receptor RET	6.2	6.1	6.7	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	8	8	8	pEC50	2
Homo sapiens	Tyrosine-protein kinase TYK2	7.7	7.5	9.4	pIC50	10
Homo sapiens	Tyrosine-protein kinase TYK2	5.9	5.9	9.1	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	9.3	9.3	9.3	pKi	8

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 Q
853

2 Q
854

3 L
855

4 G
856

5 K
857

6 G
858

7 N
859

8 F
860

9 G
861

10 S
862

11 V
863

12 E
864

13 M
865

14 V
879

15 A
880

16 V
881

17 K
882

18 K
883

19 L
884

20 D
894

•

αC

b.l

21 F
895

22 E
896

23 R
897

24 E
898

25 I
899

26 E
900

27 I
901

28 L
902

29 K
903

30 S
904

31 L
905

32 Q
906

33 D
908

34 N
909

35 I
910

36 V
911

37 K
912

38 Y
913

39 K
914

40 G
915

•

hinge

linker

αD

αE

41 V
916

42 K
926

43 L
927

44 I
928

45 M
929

46 E
930

47 Y
931

48 L
932

49 P
933

50 Y
934

51 G
935

52 S
936

53 L
937

54 R
938

55 D
939

56 Y
940

57 L
941

58 Q
942

59 K
943

60 Y
966

•

••

αE

c.l

VII

VIII

61 L
967

62 G
968

63 T
969

64 K
970

65 R
971

66 Y
972

67 I
973

68 H
974

69 R
975

70 D
976

71 L
977

72 A
978

73 T
979

74 R
980

75 N
981

76 I
982

77 L
983

78 V
984

79 I
992

80 G
993

•

DFG

a.l

81 D
994

82 F
995

83 G
996

84 L
997

85 T
998

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: