Search results (236 entries covering 103 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	JAK2	JakA	TK	8bx6	A	B	cerdulatinib	Human	Show
	JAK2	JakA	TK	8bx6	A	A	cerdulatinib	Human	Show
	JAK2	JakA	TK	3e64	A	A	4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide	Human	Show
	JAK2	JakA	TK	5wev	A	A	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	Show
	JAK2	JakA	TK	6vgl	B		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6wtn	A	A	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	8bpv	A	B	11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene	Human	Show
	JAK2	JakA	TK	3lpb	A	A	n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	5tq6	A		{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone	Human	Show
	JAK2	JakA	TK	4bbf	D		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	Show
	JAK2	JakA	TK	7uyw	A	A	2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one	Human	Show
	JAK2	JakA	TK	5cf4	B		n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4f08	B		1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4iva	A	A	trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile	Human	Show
	JAK2	JakA	TK	4aqc	B	B	8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	3tjd	B		4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4aqc	A	A	8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	4e4m	A		1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4iva	A	B	trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile	Human	Show
	JAK2	JakA	TK	7teu	A	A	3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide	Human	Show
	JAK2	JakA	TK	8g8x	A	A	3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol	Human	Show
	JAK2	JakA	TK	8g8o	A	B	[1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	8g6z	A	A	(3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	8g8o	A	A	[1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	3jy9	A	B	(3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one	Human	Show
	JAK2	JakA	TK	7teu	A	B	3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide	Human	Show
	JAK2	JakA	TK	4c61	A		n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	5tq3	B	A	4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol	Human	Show
	JAK2	JakA	TK	3q32	A		2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone	Human	Show
	JAK2	JakA	TK	8g6z	A	B	(3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6aaj	A		4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	Show
	JAK2	JakA	TK	8g8x	A	B	3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol	Human	Show
	JAK2	JakA	TK	6drw	A	B	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show
	JAK2	JakA	TK	4gfm	A	A	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	8bm2	A	B	3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine	Human	Show
	JAK2	JakA	TK	8bx9	A	B	ilginatinib	Human	Show
	JAK2	JakA	TK	8bxc	A	A	itacitinib	Human	Show
	JAK2	JakA	TK	5tq7	B		{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone	Human	Show
	JAK2	JakA	TK	7q7i	A	A	4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol	Human	Show
	JAK2	JakA	TK	3krr	A	A	8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline	Human	Show
	JAK2	JakA	TK	4hge	B	A	n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	JAK2	JakA	TK	7q7k	A	A	4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol	Human	Show
	JAK2	JakA	TK	6vnb	A		(3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6vsn	D		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6vng	B		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	Show
	JAK2	JakA	TK	6vnf	B	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	6wtp	A	B	tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate	Human	Show
	JAK2	JakA	TK	5aep	A	B	1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide	Human	Show
	JAK2	JakA	TK	3krr	A	B	8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline	Human	Show
	JAK2	JakA	TK	4e4m	D		1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	8bxh	A	A	momelotinib	Human	Show
	JAK2	JakA	TK	6wtq	A	A	n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide	Human	Show
	JAK2	JakA	TK	4bbe	D		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	Show
	JAK2	JakA	TK	3kck	A	A	3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol	Human	Show
	JAK2	JakA	TK	6vnj	A	A	3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6tpd	A		3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one	Human	Show
	JAK2	JakA	TK	3io7	A		(3s)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-n,n-diethylpiperidine-3-carboxamide	Human	Show
	JAK2	JakA	TK	4ytc	A	B	n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine	Human	Show
	JAK2	JakA	TK	6vnh	B		n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide	Human	Show
	JAK2	JakA	TK	4aqc	A	B	8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	6vgl	D		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6x8e	A	B	[3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	5usy	B	B	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show
	JAK2	JakA	TK	6vn8	A		baricitinib	Human	Show
	JAK2	JakA	TK	5tq7	A		{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone	Human	Show
	JAK2	JakA	TK	6wto	A	A	baricitinib	Human	Show
	JAK2	JakA	TK	5tq6	B		{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone	Human	Show
	JAK2	JakA	TK	5cf8	B	B	n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4bbe	C		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	Show
	JAK2	JakA	TK	7ll4	A	A	{1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile	Human	Show
	JAK2	JakA	TK	4ytf	A	B	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide	Human	Show
	JAK2	JakA	TK	7ree	A	A	[3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	6vgl	C		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4e6d	B	B	3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	5tq3	A	B	4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol	Human	Show
	JAK2	JakA	TK	2xa4	B	B	5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	4bbf	C		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	Show
	JAK2	JakA	TK	6bbv	A		n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide	Human	Show
	JAK2	JakA	TK	4bbe	A		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	Show
	JAK2	JakA	TK	5cf4	A		n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4yth	A	B	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide	Human	Show
	JAK2	JakA	TK	6vnf	B	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	8bx9	A	A	ilginatinib	Human	Show
	JAK2	JakA	TK	6vnh	A		n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide	Human	Show
	JAK2	JakA	TK	5cf8	A	A	n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4p7e	A		n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide	Human	Show
	JAK2	JakA	TK	3lpb	B	B	n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	3zmm	A	A	5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	3jy9	A	A	(3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one	Human	Show
	JAK2	JakA	TK	6vs3	B		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	5cf5	B		n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	3fup	B		3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	6vnk	D		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4ji9	B		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	4d1s	A	B	2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	4c61	B		n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	3zmm	B	A	5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	4e6d	B	A	3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	6vnk	A		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4yti	A	A	(2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide	Human	Show
	JAK2	JakA	TK	4e6d	A	A	3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	4e6q	A		1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4p7e	B		n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide	Human	Show
	JAK2	JakA	TK	3kck	A	B	3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol	Human	Show
	JAK2	JakA	TK	5l3a	A	A	~{n}-(1~{h}-indazol-4-yl)methanesulfonamide	Human	Show
	JAK2	JakA	TK	4ytf	A	A	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide	Human	Show
	JAK2	JakA	TK	5hez	C		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	3e63	A	A	5-phenyl-1h-indazol-3-amine	Human	Show
	JAK2	JakA	TK	4e6q	B		1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	5cf6	B		n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	5tq3	A	A	4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol	Human	Show
	JAK2	JakA	TK	5tq3	B	B	4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol	Human	Show
	JAK2	JakA	TK	6vni	A		2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione	Human	Show
	JAK2	JakA	TK	7uyw	A	B	2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one	Human	Show
	JAK2	JakA	TK	4e6d	A	B	3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	3tjc	A		4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	2w1i	A		4-[(2-{4-[(cyclopropylcarbamoyl)amino]-1h-pyrazol-3-yl}-1h-benzimidazol-6-yl)methyl]morpholin-4-ium	Human	Show
	JAK2	JakA	TK	3tjd	A		4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	3e63	A	B	5-phenyl-1h-indazol-3-amine	Human	Show
	JAK2	JakA	TK	4yti	A	B	(2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide	Human	Show
	JAK2	JakA	TK	6vgl	A		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	3iok	A	A	3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	7q7k	A	B	4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol	Human	Show
	JAK2	JakA	TK	8bpw	A	B	lestaurtinib	Human	Show
	JAK2	JakA	TK	3e64	A	B	4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide	Human	Show
	JAK2	JakA	TK	4gmy	A		2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	Show
	JAK2	JakA	TK	6x8e	B	B	[3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	6vnk	B		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6x8e	A	A	[3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	3q32	B		2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone	Human	Show
	JAK2	JakA	TK	6vnf	A	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	5tq4	A		6-(2-ethyl-4-hydroxyphenyl)-1h-indazole-3-carboxamide	Human	Show
	JAK2	JakA	TK	5hez	D		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	7q7w	A	A	4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol	Human	Show
	JAK2	JakA	TK	4bbe	B		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	Show
	JAK2	JakA	TK	6vnc	B		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	7q7i	A	B	4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol	Human	Show
	JAK2	JakA	TK	5cf8	A	B	n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	6vne	A		n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide	Human	Show
	JAK2	JakA	TK	8bpv	A	A	11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene	Human	Show
	JAK2	JakA	TK	8bxc	A	B	itacitinib	Human	Show
	JAK2	JakA	TK	7q7l	A	B	4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol	Human	Show
	JAK2	JakA	TK	8bm2	A	A	3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine	Human	Show
	JAK2	JakA	TK	7rn6	A	B	5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide	Human	Show
	JAK2	JakA	TK	6vsn	C		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4f09	A		2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	6vnm	B		4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	6wtn	A	B	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	5tq8	A		{2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2h-indazol-3-yl]-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone	Human	Show
	JAK2	JakA	TK	6vnl	D		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	6drw	A	A	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show
	JAK2	JakA	TK	5tq5	A		6-(2-ethyl-4-hydroxyphenyl)-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide	Human	Show
	JAK2	JakA	TK	4e4m	B		1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4c62	B		n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine	Human	Show
	JAK2	JakA	TK	6vsn	A		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4jia	A	B	5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	3ugc	A	B	5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide	Human	Show
	JAK2	JakA	TK	2b7a	B		2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one	Human	Show
	JAK2	JakA	TK	7q7w	A	B	4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol	Human	Show
	JAK2	JakA	TK	6wtp	A	A	tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate	Human	Show
	JAK2	JakA	TK	6vnl	B		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	4gfm	A	B	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	4e4m	E		1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4d1s	A	A	2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	4d0x	A	A	5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	3lpb	A	B	n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	5usy	B	A	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show
	JAK2	JakA	TK	4zim	A	B	3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide	Human	Show
	JAK2	JakA	TK	5cf8	B	A	n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	6vnm	A		4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	5hez	B		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	6vnl	C		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	5wev	A	B	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	Show
	JAK2	JakA	TK	4hge	A	A	n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	JAK2	JakA	TK	8bpw	A	A	lestaurtinib	Human	Show
	JAK2	JakA	TK	4f08	A		1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine	Human	Show
	JAK2	JakA	TK	4bbf	B		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	Show
	JAK2	JakA	TK	6vn8	B		baricitinib	Human	Show
	JAK2	JakA	TK	3ugc	A	A	5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide	Human	Show
	JAK2	JakA	TK	4zim	A	A	3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide	Human	Show
	JAK2	JakA	TK	6vsn	B		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	3tjc	B		4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	3lpb	B	A	n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	4jia	A	A	5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	4zim	B	B	3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide	Human	Show
	JAK2	JakA	TK	3zmm	B	B	5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	7rn6	A	A	5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide	Human	Show
	JAK2	JakA	TK	2xa4	B	A	5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	3fup	A		3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile	Human	Show
	JAK2	JakA	TK	4bbf	A		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	Show
	JAK2	JakA	TK	5aep	A	A	1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide	Human	Show
	JAK2	JakA	TK	2xa4	A	B	5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	2xa4	A	A	5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	2b7a	A		2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one	Human	Show
	JAK2	JakA	TK	3e62	A	A	5-bromo-1h-indazol-3-amine	Human	Show
	JAK2	JakA	TK	5usy	A	A	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show
	JAK2	JakA	TK	5l3a	A	B	~{n}-(1~{h}-indazol-4-yl)methanesulfonamide	Human	Show
	JAK2	JakA	TK	3zmm	A	B	5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	3e62	A	B	5-bromo-1h-indazol-3-amine	Human	Show
	JAK2	JakA	TK	3iok	A	B	3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine	Human	Show
	JAK2	JakA	TK	5hez	A		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	6x8e	B	A	[3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	6vne	B		n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide	Human	Show
	JAK2	JakA	TK	3rvg	A		1-(cyclohexylamino)-7-(1-methyl-1h-pyrazol-4-yl)-5h-pyrido[4,3-b]indole-4-carboxamide	Human	Show
	JAK2	JakA	TK	4d0w	A	B	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	7ll5	A	A	{1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile	Human	Show
	JAK2	JakA	TK	6aaj	B		4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	Show
	JAK2	JakA	TK	4ji9	A		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	Show
	JAK2	JakA	TK	6vnk	C		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6vnf	A	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	Show
	JAK2	JakA	TK	5cf5	A		n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	5cf6	A		n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide	Human	Show
	JAK2	JakA	TK	4hge	B	B	n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	JAK2	JakA	TK	7q7l	A	A	4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol	Human	Show
	JAK2	JakA	TK	7ll4	A	B	{1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile	Human	Show
	JAK2	JakA	TK	6vng	A		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	Show
	JAK2	JakA	TK	7ree	A	B	[3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile	Human	Show
	JAK2	JakA	TK	7ll5	A	B	{1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile	Human	Show
	JAK2	JakA	TK	2w1i	B		-	Human	Show
	JAK2	JakA	TK	6vnl	A		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	Show
	JAK2	JakA	TK	6vnc	A		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4ytc	A	A	n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine	Human	Show
	JAK2	JakA	TK	4d0x	A	B	5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	4d0w	A	A	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide	Human	Show
	JAK2	JakA	TK	4yth	A	A	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide	Human	Show
	JAK2	JakA	TK	4hge	A	B	n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	Human	Show
	JAK2	JakA	TK	4aqc	B	A	8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Human	Show
	JAK2	JakA	TK	8bxh	A	B	momelotinib	Human	Show
	JAK2	JakA	TK	4c62	A		n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine	Human	Show
	JAK2	JakA	TK	6wtq	A	B	n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide	Human	Show
	JAK2	JakA	TK	4zim	B	A	3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide	Human	Show
	JAK2	JakA	TK	6wto	A	B	baricitinib	Human	Show
	JAK2	JakA	TK	6vs3	A		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	6vnj	B	A	3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	Show
	JAK2	JakA	TK	4iva	A	C	trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile	Human	Show
	JAK2	JakA	TK	5usy	A	B	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam