Version: 3.2
Updated: 29-Oct-2025
Mitogen-activated protein kinase-activated protein kinase 2
Kinase structure
Kinase:MAPKAPK2
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2094
PDB:2P3G
sc-PDB:
KIDFamMap:Search
Release date:2007-06-12
PubMed: 17480064
Chain:X
Orthosteric ligand:F10
2D structure of the orthosteric ligand
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):55.1° (16Å)
G-rich loop rotation:87°
Quality Score:8
Resolution:3.8 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
PocketsSubpockets
front

Pocket alignment
Uniprot sequence:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA
Sequence structure:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA

Ligand affinity
ChEMBL ID:CHEMBL226471
Bioaffinities: 58 records for 46 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensAMP-activated protein kinase, alpha-1 subunit5.85.85.8pKi1
Homo sapiensBR serine/threonine-protein kinase 15.95.95.9pKi1
Homo sapiensCasein kinase I alpha5.75.75.7pKi1
Homo sapiensCasein kinase I delta666pKi1
Homo sapiensCasein kinase I gamma 16.26.26.2pKi1
Homo sapiensCasein kinase I gamma 26.86.86.8pKi1
Homo sapiensCasein kinase II alpha5.85.85.8pKi1
Homo sapiensc-Jun N-terminal kinase 16.86.86.8pKi1
Homo sapiensc-Jun N-terminal kinase 24.74.74.7pIC501
Homo sapiensc-Jun N-terminal kinase 26.56.56.5pKi1
Homo sapiensCyclin-dependent kinase 14.54.54.5pIC501
Homo sapiensCyclin-dependent kinase 15.55.55.5pKi1
Homo sapiensDeath-associated protein kinase 36.26.26.2pKi1
Homo sapiensDual specificity protein kinase CLK25.95.95.9pKi1
Homo sapiensDual specificity protein kinase CLK46.56.56.5pKi1
Homo sapiensDual-specificity tyrosine-phosphorylation regulated kinase 1A888pKi1
Homo sapiensDual-specificity tyrosine-phosphorylation regulated kinase 36.76.76.7pKi1
Homo sapiensEpidermal growth factor receptor erbB16.26.26.2pKi1
Homo sapiensGlycogen synthase kinase-3 alpha5.45.45.4pKi1
Homo sapiensHepatocyte growth factor receptor5.95.95.9pKi1
Homo sapiensInterleukin-1 receptor-associated kinase 15.95.95.9pKi1
Homo sapiensMAP kinase-activated protein kinase 25.65.66.4pEC502
Homo sapiensMAP kinase-activated protein kinase 25.45.16.9pIC504
Homo sapiensMAP kinase-activated protein kinase 3666pIC501
Homo sapiensMAP kinase-activated protein kinase 35.65.65.6pKi1
Homo sapiensMAP kinase-activated protein kinase 56.76.76.7pIC501
Homo sapiensMAP kinase-activated protein kinase 56.66.66.6pKi1
Homo sapiensMAP kinase ERK25.35.35.3pIC501
Homo sapiensMAP kinase ERK25.85.85.8pKi1
Homo sapiensMAP kinase p38 alpha4.14.14.1pIC501
Homo sapiensMAP kinase p38 delta5.85.85.8pKi1
Homo sapiensMAP kinase p38 gamma5.75.75.7pKi1
Homo sapiensMAP kinase signal-integrating kinase 25.85.85.8pKi1
Homo sapiensMaternal embryonic leucine zipper kinase5.85.85.8pKi1
Homo sapiensMisshapen-like kinase 16.66.66.6pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 2666pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 47.67.67.6pKi1
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 56.26.26.2pKi1
Homo sapiensProtein kinase C nu6.56.56.5pKi1
Homo sapiensRibosomal protein S6 kinase 1666pKi1
Homo sapiensRibosomal protein S6 kinase alpha 44.24.24.2pIC502
Homo sapiensSerine/threonine-protein kinase 25.45.45.4pKi1
Homo sapiensSerine/threonine-protein kinase Aurora-B5.25.25.2pKi1
Homo sapiensSerine/threonine-protein kinase Chk26.26.26.2pKi1
Homo sapiensSerine/threonine-protein kinase D26.66.66.6pKi1
Homo sapiensSerine/threonine-protein kinase Nek45.25.25.2pKi1
Homo sapiensSerine/threonine-protein kinase PIM16.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase PLK46.16.16.1pKi1
Homo sapiensSerine/threonine-protein kinase SRPK15.45.45.4pKi1
Homo sapiensTyrosine-protein kinase JAK36.36.36.3pIC502
Homo sapiensTyrosine-protein kinase receptor UFO5.85.85.8pKi1
Homo sapiensVascular endothelial growth factor receptor 25.15.15.1pKi1


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 Q
68		2 V
69		3 L
70		4 G
71		5 L
72		6 G
73		7 I
74		8 N
75		9 G
76		10 K
77		11 V
78		12 L
79		13 Q
80		14 F
90		15 A
91		16 L
92		17 K
93		18 M
94		19 L
95		20 K
100
•••••
αC b.l IV
21 A
101		22 R
102		23 R
103		24 E
104		25 V
105		26 E
106		27 L
107		28 H
108		29 W
109		30 R
110		31 A
111		32 S
112		33 P
115		34 H
116		35 I
117		36 V
118		37 R
119		38 I
120		39 V
121		40 D
122
•
IV V GK hinge linker αD αE
41 V
123		42 L
135		43 I
136		44 V
137		45 M
138		46 E
139		47 C
140		48 L
141		49 D
142		50 G
143		51 G
144		52 E
145		53 L
146		54 F
147		55 S
148		56 R
149		57 I
150		58 Q
151		59 D
152		60 Y
176
••••••
αE VI c.l VII VIII x
61 L
177		62 H
178		63 S
179		64 I
180		65 N
181		66 I
182		67 A
183		68 H
184		69 R
185		70 D
186		71 V
187		72 K
188		73 P
189		74 E
190		75 N
191		76 L
192		77 L
193		78 Y
194		79 L
205		80 T
206
••
DFG a.l
81 D
207		82 F
208		83 G
209		84 F
210		85 A
211
••

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