Version: 3.2
Updated: 29-Oct-2025
Mitogen-activated protein kinase-activated protein kinase 2
Kinase structure
Kinase:MAPKAPK2
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2094
PDB:2PZY
sc-PDB:
KIDFamMap:Search
Release date:2007-07-31
PubMed: 17576063
Chain:D
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The orthosteric binding pocket


More entries for 2PZY
2PZYChain: A
2PZYChain: B
2PZYChain: C


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):48° (14.4Å)
G-rich loop rotation:72.7°
Quality Score:8
Resolution:2.9 Å
Missing Residues:0
Missing Atoms:0

Pocket alignment
Uniprot sequence:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA
Sequence structure:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA