Version: 3.2
Updated: 29-Oct-2025
P21 protein (Cdc42/Rac)-activated kinase 4
Kinase structure
Kinase:PAK4
Family:STE20
Group:STE
Species:HUMAN
IUPHAR/BPS ID:2136
PDB:2J0I
sc-PDB:
KIDFamMap:Search
Release date:2006-08-17
Chain:A
(Alternate) Model:A
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The orthosteric binding pocket


More entries for 2J0I
2J0IAlternative model: BChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):48.6° (14.7Å)
G-rich loop rotation:61.2°
Quality Score:9.4
Resolution:1.6 Å
Missing Residues:0
Missing Atoms:6
Ligand binding mode
Waters
Cluster
I1
I2
I3
I4
I5
I6
I9
I10
I11
Ligand
No
No
No
No
No
No
No
No
No
Protein
Yes
No
Yes
Yes
Yes
Yes
No
Yes
Yes

Pocket alignment
Uniprot sequence:IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYQENVVEMYNSWVVMEFLEGGALTDIVTHVLHAQGVIHRDIKSDSILLLSDFGFC
Sequence structure:IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYQENVVEMYNSWVVMEFLEGGALTDIVTHVLHAQGVIHRDIKSDSILLLSDFGFC