Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Kinase structure
Kinase:PIK3CA (p110a)
Family:PIK
Group:Atypical
Species:HUMAN
IUPHAR/BPS ID:2153
PDB:8DCX
sc-PDB:
KIDFamMap:Search
Release date:2022-09-21
PubMed: 36095215
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):55.3° (16.5Å)
G-rich loop rotation:64.1°
Quality Score:7.6
Resolution:2.8 Å
Missing Residues:0
Missing Atoms:0

Pocket alignment
Uniprot sequence:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI--LGIGDRHNSNIMVHIDFGHF
Sequence structure:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI__LGIGDRHNSNIMVHIDFGHF