Search results (134 entries covering 100 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	PIK3CA (p110a)	PIK	Atypical	8twy	A		n-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exo	A	B	1-{(4s,11am)-2-[(4r)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-prolinamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exl	A	A	2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1h-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1h-pyrazol-1-yl)propanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exo	A	A	1-{(4s,11am)-2-[(4r)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-prolinamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exv	A	A	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8gud	A	A	(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvh	A	A	5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8sbc	A	A	(2m)-7-[(3r)-3-methylmorpholin-4-yl]-5-[(3s)-3-methylmorpholin-4-yl]-2-(pyridin-2-yl)-1h-imidazo[4,5-b]pyridine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7pg6	A	A	(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7tz7	A	A	(4s,5r)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7myn	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8v8i	A		(2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8v8v	A		(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8v8u	A		(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8v8j	A		(2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7tz7	A	B	(4s,5r)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5uk8	A	B	(r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4ovu	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6pys	A	B	(3s)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2h-indol-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4ovv	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7mlk	A	B	4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4ovu	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxb	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5swo	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxc	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tgd	A	B	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ils	A	B	n-[(2r)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tu6	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ilv	A		n-[(2r)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8w9b	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8w9a	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5fi4	A	B	~{n}-[6-[5-azanyl-6-[(2~{s})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]ethanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ow2	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tsb	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tsc	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ts7	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ts9	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tsa	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7myo	B	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5fi4	A	A	~{n}-[6-[5-azanyl-6-[(2~{s})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]ethanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6oac	A		4-(difluoromethyl)-5-{4-[(3s)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4tuu	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5ul1	A	B	3-amino-6-(4-{[(2s)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-n-phenylpyrazine-2-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4l1b	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6n	A	B	tert-butyl (3s)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7h-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvf	A	B	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvf	A	A	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7myn	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5swg	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5swr	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k71	A		2-(morpholin-4-yl)[4,5'-bipyrimidin]-2'-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sx9	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvi	A	B	3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7r9v	A		n-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4waf	A	B	n,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5ubr	A		1-[4-(3-{4-amino-5-[1-(oxan-4-yl)-1h-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)piperazin-1-yl]ethan-1-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4jps	A	A	(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6n	A	A	tert-butyl (3s)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7h-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sw8	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5dxh	D		methyl {2-[4-(2-chlorophenyl)-4h-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepin-8-yl}carbamate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sx8	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5swp	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxd	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5dxh	A		methyl {2-[4-(2-chlorophenyl)-4h-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepin-8-yl}carbamate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4zop	A	B	(2s,3r)-n~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7myo	B	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4ykn	A	A	3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6nct	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxf	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvh	A	B	5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5swt	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4zop	A	A	(2s,3r)-n~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5xgi	A		3-azanyl-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tdu	A	B	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ts8	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7jiu	A	B	(3s)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9h-purin-6-yl]-3-methyl-1,3-dihydro-2h-indol-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxe	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5xgh	A		3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4waf	A	A	n,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxk	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6m	A	B	2,2-difluoroethyl (3s)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxi	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7r9y	A		n-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-n-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	3hhm	A		(1s,6br,9as,11r,11br)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3h-furo[4,3,2-de]indeno[4,5-h][2]benzopyran-11-yl acetate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8am0	A		(2r)-2-[[2-[(4s)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tdu	A	A	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvi	A	A	3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5itd	A		5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8bfu	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8sbj	A	B	(2m)-7-[(3r)-3-methylmorpholin-4-yl]-5-[(3s)-3-methylmorpholin-4-yl]-2-(1h-pyrazol-3-yl)-3h-imidazo[4,5-b]pyridine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dd8	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8sbj	A	A	(2m)-7-[(3r)-3-methylmorpholin-4-yl]-5-[(3s)-3-methylmorpholin-4-yl]-2-(1h-pyrazol-3-yl)-3h-imidazo[4,5-b]pyridine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7pg5	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dcp	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5ul1	A	A	3-amino-6-(4-{[(2s)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-n-phenylpyrazine-2-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6o	A	B	(3s)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7h-pyrrolo[2,3-d]pyrimidin-7-yl]-n-methylpyrrolidine-1-sulfonamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxj	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5dxt	A		(2s)-2-({2-[1-(propan-2-yl)-1h-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7pg5	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5sxa	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7jiu	A	A	(3s)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9h-purin-6-yl]-3-methyl-1,3-dihydro-2h-indol-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7mlk	A	A	4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8v8h	A		(2s)-n~1~-[(4p)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exl	A	B	2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1h-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1h-pyrazol-1-yl)propanamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6m	A	A	2,2-difluoroethyl (3s)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dcx	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ilr	A	B	n-[(2s)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	3zim	A		1-[4-[[2-(1h-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4-dione	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4tv3	A		2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5uk8	A	A	(r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5ukj	A		n,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7k6o	A	A	(3s)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7h-pyrrolo[2,3-d]pyrimidin-7-yl]-n-methylpyrrolidine-1-sulfonamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	2rd0	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4l23	A		3-(4-morpholin-4-ylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6pys	A	A	(3s)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2h-indol-2-one	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4l2y	A		3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol	Human	Show
	PIK3CA (p110a)	PIK	Atypical	6gvg	A		5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	3hiz	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4jps	A	B	(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exv	A	B	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	5xgj	A		3-(4-morpholin-4-ylfuro[3,2-d]pyrimidin-2-yl)-5-[(phenylmethyl)amino]phenol	Human	Show
	PIK3CA (p110a)	PIK	Atypical	4ykn	A	B	3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exu	A	A	(2s)-2-cyclopropyl-2-({(4s,11am)-2-[(4s)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)acetamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8gua	A		(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8ow2	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dd4	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dd4	A	B	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8sbc	A	B	(2m)-7-[(3r)-3-methylmorpholin-4-yl]-5-[(3s)-3-methylmorpholin-4-yl]-2-(pyridin-2-yl)-1h-imidazo[4,5-b]pyridine	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8dcp	A	A	-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tsd	A		-	Human	Show
	PIK3CA (p110a)	PIK	Atypical	7pg6	A	B	(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8tgd	A	A	n~2~-{(4s,11ap)-2-[(4s)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-l-alaninamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8gub	A		(2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide	Human	Show
	PIK3CA (p110a)	PIK	Atypical	8exu	A	B	(2s)-2-cyclopropyl-2-({(4s,11am)-2-[(4s)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)acetamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam