KLIFS - the kinase structures database

Version: 3.2
Updated: 24-Dec-2025

Eukaryotic translation initiation factor 2 alpha kinase 3

Kinase structure
Kinase:	EIF2AK3 (PEK)
Family:	PEK
Group:	Other
Species:	HUMAN
IUPHAR/BPS ID:	2017
PDB:	8EQD
sc-PDB:
KIDFamMap:	Search
Release date:	2022-11-30
PubMed:	36297668
Chain:	A
Orthosteric ligand:	WPX

Structural information
DFG conformation:	in
αC-helix conformation:	na
G-rich loop angle (distance):	-
G-rich loop rotation:	-
Quality Score:	4
Resolution:	2.92 Å
Missing Residues:	41
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front gate back	BP-I-B BP-II-in

Pocket alignment
Uniprot sequence:	QCLGRGGFGVVFEYAIKRIKVMREVKALAKLEPGIVRYFNAYIQMQLCRKENLKDWMNGFLHSKGLMHRDLKPSNIFFVGDFGLV
Sequence structure:	_________________________________________YIQMQLCRKENLKDWMNGFLHSKGLMHRNLKPSNIFFVGDFGLV

Ligand affinity
Ligand not found in ChEMBL.

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 _
_

2 _
_

3 _
_

4 _
_

5 _
_

6 _
_

7 _
_

8 _
_

9 _
_

10 _
_

11 _
_

12 _
_

13 _
_

14 _
_

15 _
_

16 _
_

17 _
_

18 _
_

19 _
_

20 _
_

αC

b.l

21 _
_

22 _
_

23 _
_

24 _
_

25 _
_

26 _
_

27 _
_

28 _
_

29 _
_

30 _
_

31 _
_

32 _
_

33 _
_

34 _
_

35 _
_

36 _
_

37 _
_

38 _
_

39 _
_

40 _
_

hinge

linker

αD

αE

41 _
_

42 Y
885

43 I
886

44 Q
887

45 M
888

46 Q
889

47 L
890

48 C
891

49 R
892

50 K
893

51 E
894

52 N
895

53 L
896

54 K
897

55 D
898

56 W
899

57 M
900

58 N
901

59 G
902

60 F
927

•

••

αE

c.l

VII

VIII

61 L
928

62 H
929

63 S
930

64 K
931

65 G
932

66 L
933

67 M
934

68 H
935

69 R
936

70 N
937

71 L
938

72 K
939

73 P
940

74 S
941

75 N
942

76 I
943

77 F
944

78 F
945

79 V
953

80 G
954

••

•

DFG

a.l

81 D
955

82 F
956

83 G
957

84 L
958

85 V
959

•

Interaction pattern search

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